术中阿片类药物用量对脑胶质瘤患者术后生存期的影响  

Effect of intraoperative opioid dosage on postoperative survival of patients with glioma

作　　者：刘雪娇 张雯惠 林施延 赵刘园 陈瑞 滕蕾 代俊竹 邵洪雪 邹慧超[1] LIU Xuejiao;ZHANG Wenhui;LIN Shiyan;ZHAO Liuyuan;CHEN Rui;TENG Lei;DAI Junzhu;SHAO Hongxue;ZOU Huichao(Department of Pain,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China)

机构地区：[1]哈尔滨医科大学附属肿瘤医院疼痛科,黑龙江哈尔滨150081

出　　处：《现代肿瘤医学》2023年第19期3640-3643,共4页Journal of Modern Oncology

基　　金：黑龙江省卫健委科研基金(编号:204-058)。

摘　　要：目的:探究术中阿片类药物剂量对胶质瘤患者术后生存期的影响。方法:回顾性分析165例接受肿瘤切除术的脑胶质瘤患者的临床资料。根据术中阿片类药物剂量中位数(2.1 mg),将患者分为高剂量组和低剂量组。采用Kaplan-Meier法绘制生存曲线、Cox风险回归模型进行影响总生存期(overall survival,OS)和无复发生存期(relapse-free survival,RFS)的单因素和多因素分析,研究高剂量组和低剂量组之间OS和RFS的关系。结果:单因素Cox回归分析发现高、低剂量组之间在RFS(HR:1.082,95%CI:0.914~1.280,P=0.360)和OS(HR:1.099,95%CI:0.925~1.305,P=0.282)方面无差异。多因素Cox回归分析发现,术中阿片类药物剂量与RFS(HR:0.807,95%CI:0.537~1.212,P=0.301)和OS(HR:0.908,95%CI:0.599~1.378,P=0.650)无关。Kaplan-Meier法生存分析结果显示,高、低剂量组之间的RFS(P=0.525)和OS(P=0.332)无统计学差异。结论:术中阿片类药物剂量与脑胶质瘤患者的无复发生存期和总生存期之间无相关性。Objective:To investigate the effect of intraoperative opioid dose on postoperative survival of patients with glioma.Methods:The clinical data of 165 patients with glioma who underwent tumor resection were analyzed retrospectively.Patients were divided into high-dose group and low-dose group according to the median intraoperative opioid dose(2.1 mg).Kaplan-Meier method was used to draw survival curve and Cox risk regression model was used to analyze the single and multiple factors affecting overall survival(OS)and relapse-free survival(RFS).The relationship in OS and RFS between high dose and low dose groups was analyzed.Results:Univariate Cox regression analysis found no difference in RFS(HR:1.082,95%CI:0.914~1.280,P=0.360)and OS(HR:1.099,95%CI:0.925~1.305,P=0.282)between the high-dose and low-dose groups.Multivariate Cox regression analysis found that intraoperative opioid dose was not correlated with RFS(HR:0.807,95%CI:0.537~1.212,P=0.301)or OS(HR:0.908,95%CI:0.599~1.378,P=0.650).Kaplan-Meier survival analysis showed no significant difference in RFS(P=0.525)and OS(P=0.332)between the high-dose and low-dose groups.Conclusion:There is no correlation between intraoperative opioid dose and relapse-free survival and overall survival in glioma patients.

关 键 词：阿片类药物 脑胶质瘤 总生存期 无复发生存期 

分 类 号：R739.41[医药卫生—肿瘤]