贝伐珠单抗联合奥拉帕尼治疗铂类敏感复发性卵巢癌的效果  

Effect of bevacizumab combined with olapamil in the treatment of platinum sensitive recurrent ovarian cancer

作　　者：王娜[1] Wang Na(Department of Hematology and Oncology,Inner Mongolia Forestry General Hospital(the Second Clinical Medical College of Inner Mongolia University for Nationalities),Hulun Buir 022150,Chinal)

机构地区：[1]内蒙古林业总医院(内蒙古民族大学第二临床医学院)血液肿瘤科,内蒙古呼伦贝尔022150

出　　处：《实用妇科内分泌电子杂志》2023年第17期68-70,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的探讨贝伐珠单抗联合奥拉帕尼治疗铂类敏感复发性卵巢癌的效果。方法采用便利抽样法选取本院82例住院治疗的铂类敏感复发性卵巢癌患者为研究对象,随机分为两组,各41例。对照组采用卡铂联合多柔比星脂质体治疗,试验组采用贝伐珠单抗联合奥拉帕尼治疗,比较两组的治疗效果、血清肿瘤标志物水平、不良反应发生情况。结果试验组的客观缓解率、疾病控制率分别为56.10%、82.93%,高于对照组的24.39%、56.10%(P<0.05);治疗后,试验组的人附睾蛋白、糖类抗原125水平低于对照组(P<0.05);试验组的口腔黏膜炎、手足综合征发生率低于对照组(P<0.05)。结论贝伐珠单抗联合奥拉帕尼治疗铂类敏感复发性卵巢癌,治疗效果显著,能明显提高客观缓解及疾病控制效果,降低血清肿瘤标志物水平,值得推广。Objective To investigate the effect of bevacizumab combined with olapamil in the treatment of platinum sensitive recurrent ovarian cancer.Methods Convenient sampling method was used to select 82 platinum sensitive recurrent ovarian cancer patients who were hospitalized in our hospital as the research subjects.They were randomly divided into two groups,with 41 patients in each group.The control group was treated with carboplatin combined with doxorubicin liposomes,and the test group was treated with bevacizumab combined with olapamil.The therapeutic effects,serum tumor marker levels,and adverse reactions of the two groups were compared.Results The objective remission rate and disease control rate of the experimental group were 56.10%and 82.93%,respectively,higher than those of the control group(24.39%and 56.10%,P<0.05);After treatment,the levels of human epididymal protein and carbohydrate antigen 125 in the experimental group were lower than those in the control group(P<0.05);The incidence of oral mucosal inflammation and hand foot syndrome in the experimental group was lower than that in the control group(P<0.05).Conclusion The combination of bevacizumab and olapamil in the treatment of platinum sensitive recurrent ovarian cancer has significant therapeutic effect,can significantly improve the objective remission and disease control effect,and reduce the level of serum tumor markers,which is worth promoting.

关 键 词：贝伐珠单抗 奥拉帕尼 复发 卵巢癌 

分 类 号：R737.31[医药卫生—肿瘤]