同步放化疗治疗局部晚期非小细胞肺癌的效果及对免疫功能和血清EGFR、TGF-α水平的影响  

Effect of concomitant radiochemotherapy on locally advanced non-small cell lung cancer and its influence on immune function and levels of serum EGFR and TGF-α

作　　者：贾亚辉 宋小珍 曾祥学 张跃强 Jia Yahui;Song Xiaozhen;Zeng Xiangxue;Zhang Yueqiang(Department of Oncology,Zhoukou Hospital of Traditional Chinese Medicine,Zhoukou 466000,China)

机构地区：[1]周口市中医院肿瘤科,周口466000

出　　处：《中国实用医刊》2023年第12期47-50,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析同步放化疗治疗局部晚期非小细胞肺癌(NSCLC)的效果及对免疫功能及血清表皮生长因子受体(EGFR)、转化生长因子-α(TGF-α)水平的影响。方法抽取2020年6月至2022年12月周口市中医院收治的90例局部晚期NSCLC患者,按随机数字表法分为对照组与观察组,每组45例。对照组采用单纯放射治疗,观察组在对照组治疗基础上进行同步化疗,均治疗9周。比较两组治疗效果,比较两组治疗前后血清EGFR、TGF-α水平及免疫功能指标[CD3^(+)、CD4^(+)、自然杀伤细胞(NK)比例和CD4^(+)/CD8^(+)],比较两组治疗期间不良反应发生率。结果治疗后,观察组客观缓解率(75.56%,34/45)高于对照组(44.44%,20/45),差异有统计学意义(P<0.05)。治疗后,两组血清EGFR、TGF-α低于治疗前,且观察组血清EGFR、TGF-α水平均低于对照组(P均<0.05)。治疗后,两组CD3^(+)、NK细胞比例低于治疗前,且观察组CD3^(+)、NK细胞比例和CD4^(+)/CD8^(+)低于对照组(P<0.05)。治疗期间,观察组不良反应发生率与对照组比较差异未见统计学意义(P>0.05)。结论相比于单纯放疗,采用同步放化疗治疗局部晚期NSCLC患者可明显提高临床治疗效果,降低血清EGFR和TGF-α水平,虽可降低机体免疫功能并增加不良反应的发生。Objective To analyze the effect of concomitant radiochemotherapy on locally advanced non-small cell lung cancer(NSCLC),and its influence on immune function and levels of serum epidermal growth factor receptor(EGFR)and transforming growth factor-α(TGF-α).Methods Ninety patients with locally advanced NSCLC who were admitted to Zhoukou Hospital of Traditional Chinese Medicine from June 2020 to December 2022 were selected.They were divided into control group and observation group by random number table method,with 45 cases in each group.The control group was only treated by radiotherapy,while observation group was treated by concomitant chemotherapy based on the treatment of the control group.All of them were treated for 9 weeks.The therapeutic effect of the two groups were compared.The levels of serum EGFR,TGF-α,and immune function indexes,including cluster of differentiation 3^(+)(CD3^(+)),cluster of differentiation 4^(+)(CD4^(+)),ratio of natural killer(NK)cells,CD4^(+)/cluster of differentiation 8^(+)(CD8^(+)),of the two groups were compared before and after treatment.The incidence of adverse reactions during treatment were compared between the two groups.Results After treatment,the objective response rate of treatment in the observation group(75.56%,34/45)was significantly higher than that in the control group(44.44%,20/45),P<0.05.After treatment,the levels of serum EGFR and TGF-αin the two groups were lower than those before treatment,and the levels of serum EGFR and TGF-αin the observation group were lower than those in control group(all P<0.05).After treatment,the CD3^(+)and ratio of NK cells of the two groups were lower than those before treatment,moreover,CD3^(+),ratio of NK cells,and CD4^(+)/CD8^(+)in the observation group were lower than those in control group(P<0.05).During treatment,there was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusions Compared with radiotherapy,concomitant radiochemotherapy can significantl

关 键 词：非小细胞肺癌 同步放化疗 表皮生长因子受体 转化生长因子-Α 免疫功能 

分 类 号：R734.2[医药卫生—肿瘤]