养肝安神汤联合西药治疗气郁化火证双相情感障碍临床研究  

Clinical Study on Yanggan Anshen Decoction Combined with Western Medicine for Bipolar Disorder with Syndrome of Qi Constraint Transforming into Fire

作　　者：张芬 林承凤 蒋晁明 贾雪珍 ZHANG Fen;LIN Chengfeng;JIANG Chaoming;JIA Xuezhen(The Second Hospital of Jinhua,Jinhua Zhejiang 321016,China)

机构地区：[1]金华市第二医院,浙江金华321016

出　　处：《新中医》2023年第17期77-80,共4页New Chinese Medicine

摘　　要：目的:观察养肝安神汤联合西药治疗气郁化火证双相情感障碍的临床疗效。方法:将90例双相情感障碍患者按奇偶法随机分为观察组与对照组各45例,对照组予以西药治疗,观察组在对照组基础上联合养肝安神汤治疗。2组均以6周为1个疗程,治疗3个疗程。比较2组临床疗效、汉密尔顿抑郁量表-17 (HAMD-17)评分、Bech-Rafaelsen躁狂量表(BRMS)评分及起效时间、症状控制时间。结果:观察组治疗总有效率88.89%,高于对照组68.89%(P<0.05)。治疗前,2组HAMD-17评分、BRMS评分比较,差异无统计学意义(P>0.05)。治疗后,2组HAMD-17评分、BRMS评分均降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,观察组起效时间及症状控制时间均短于对照组(P<0.05)。结论:养肝安神汤联合西药治疗气郁化火证双相情感障碍能在较短时间内缓解患者狂躁、抑郁状态,起效快,可有效控制临床症状,疗效确切。Objective:To observe the clinical effect of Yanggan Anshen Decoction combined with western medicine for bipolar disorder with syndrome of qi constraint transforming into fire.Methods:A total of 90 cases of patients with bipolar disorder were randomly divided into the observation group and the control group according to the parity method,with 45 cases in each group.The control group was treated with western medicine,and the observation group was additionally treated with Yanggan Anshen Decoction based on the treatment of the control group.Both two groups were treated with a course of 6 weeks for 3 courses.The clinical effects,Hamilton Depression Scale-17(HAMD-17)scores,Bech-Rafaelsen Mania Scale(BRMS)scores,onset time,and symptom control time were compared between the two groups.Results:The total effective rate was 88.89%in the observation group,higher than that of 68.89%in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the scores of HAMD-17 and BRMS between the two groups(P>0.05).After treatment,the scores of HAMD-17 and BRMS in the two groups were decreased(P<0.05),and the above scores in the observation group were lower than those in the control group(P<0.05).After treatment,the onset time and symptom control time in observation group were shorter than those in the control group(P<0.05).Conclusion:Yanggan Anshen Decoction combined with western medicine for bipolar disorder with syndrome of qi constraint transforming into fire can relieve the manic and depressive states of patients in a short time,which takes effect quickly,and the clinical symptoms can be effectively controlled with a definite curative effect.

关 键 词：双相情感障碍 气郁化火证 养肝安神汤 汉密尔顿抑郁量表-17 Bech-Rafaelsen躁狂量表 

分 类 号：R749.4[医药卫生—神经病学与精神病学]