溶血磷脂酰胆碱酰基转移酶1在宫颈癌中的表达及临床意义  

Expression and clinical significance of lysophosphatidylcholine acyltransferase 1 in cervical cancer

作　　者：陈韩[1] 杨江怡 陈华[2] 韩锋 Chen Han;Yang Jiangyi;Chen Hua;Han Feng(Department of Laboratory,the First Affiliated Hospital of Hainan Medical College,Hainan Province,Haikou 570102,China;不详)

机构地区：[1]海南医学院第一附属医院检验科,570102 [2]海南医学院第一附属医院妇科,570102

出　　处：《疑难病杂志》2023年第10期1051-1055,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：海南省自然科学基金资助项目(821MS0779)。

摘　　要：目的探讨溶血磷脂酰胆碱酰基转移酶1(LPCAT1)在宫颈癌中的表达及其临床意义。方法选取2012年1月1日—2022年12月31日海南医学院第一附属医院妇科手术治疗宫颈癌患者163例作为观察组,另选取同期因患子宫平滑肌瘤施行全子宫切除术患者77例作为对照组。采用免疫组织化学法检测LPCAT1蛋白在宫颈癌组织和正常宫颈组织中的表达水平,比较LPCAT1蛋白水平在不同宫颈癌患者临床病理特征中的差异,运用Kaplan-Meier法分析LPCAT1蛋白表达与宫颈癌患者术后预后的关系,Cox回归模型分析宫颈癌术后预后的影响因素。结果宫颈癌组织中LPCAT1蛋白高表达率显著高于正常宫颈组织(χ^(2)=18.509,P<0.001);FIGO分期Ⅲ~Ⅳ期、浸润深度>1/2肌层、淋巴结转移、中高分化宫颈癌患者LPCAT1蛋白高表达率高于FIGO分期Ⅰ~Ⅱ期、浸润深度≤1/2肌层、无淋巴结转移、低分化者(χ^(2)/P=5.501/0.019,20.463/<0.001,5.979/0.014,21.675/<0.001);LPCAT1蛋白高表达者总生存率显著低于低表达者(χ^(2)=4.791,P=0.029);FIGO分期Ⅲ~Ⅳ期、肿瘤浸润深度>1/2肌层、淋巴结转移、中高分化和LPCAT1蛋白高表达均为宫颈癌患者术后预后的独立危险因素[HR(95%CI)=1.564(1.284~2.122),1.376(1.069~1.972),2.439(1.300~3.950),2.690(2.049~3.699),1.302(1.068~1.590)]。结论LPCAT1蛋白在宫颈癌组织中呈现高表达,且其高表达可提示宫颈癌患者术后预后不良。LPCAT1蛋白可能具有作为宫颈癌早期诊断和预后预测生物标志物的潜能。Objective To investigate the expression and clinical significance of lysophosphatidylcholine acyltransferase 1(LPCAT1)in cervical cancer.Methods One hundred and sixty-three patients with cervical cancer who underwent gynecological surgery at the First Affiliated Hospital of Hainan Medical College from January 1,2012 to December 31,2022 were selected as the observation group,and 77 patients who underwent total hysterectomy for uterine leiomyoma during the same period were selected as the control group.Immunohistochemical method was used to detect the expression level of LPCAT1 protein in cervical cancer tissue and normal cervical tissue,and the differences in clinical pathological characteristics of different cervical cancer patients were compared.Kaplan Meier method was used to analyze the relationship between LPCAT1 protein expression and postoperative prognosis of cervical cancer patients.Cox regression model was used to analyze the influencing factors of postoperative prognosis of cervical cancer patients.Results The high expression rate of LPCAT1 protein in cervical cancer tissue is significantly higher than that in normal cervical tissue(χ^(2)=18.509,P<0.001);High expression of LPCAT1 protein in cervical cancer tissues with FIGO stage III-IV,infiltration depth>1/2 muscle layer,lymph node metastasis,high differentiation in tissues higher than FIGO stage I-II,infiltration depth≤1/2 muscle layer,no lymph node metastasis,and low differentiation(χ^(2)/P=5.501/0.019,20.463/<0.001,5.979/0.014,21.675/<0.001).The overall survival rate of individuals with high expression of LPCAT1 protein is significantly lower than those with low expression(χ^(2)=4.791,P=0.029);FIGO staging stages III-IV,tumor infiltration depth>1/2 muscle layer,lymph node metastasis,medium to high differentiation,and high expression of LPCAT1 protein are independent risk factors for postoperative prognosis of cervical cancer patients[HR(95%CI)=1.564(1.284-2.122),1.376(1.069-1.972),2.439(1.300-3.950),2.690(2.049-3.699),1.302(1.068-1.590)].Conclu

关 键 词：宫颈癌 溶血磷脂酰胆碱酰基转移酶1 表达 预后 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]