肠上皮化生癌变相关分子标志物的研究进展  

Research progress of molecules markers related to intestinal metaplasia-gastric cancer

作　　者：庞丽兴 陆才金(综述) 颜新(审校) Pang Lixing;Lu Caijin;Yan Xin(Third Affiliated Hospital of Guangxi Medical University/Department of Gastroenterology,Nanning Second People's Hospital,Guangxi Province,Nanning 530000,China)

机构地区：[1]广西医科大学第三附属医院/南宁市第二人民医院消化内科,530000

出　　处：《疑难病杂志》2023年第10期1116-1120,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：国家自然科学基金资助项目(82060740);广西壮族自治区卫生健康委员会自筹课题(Z-A20221188,Z20190717);南宁市科技局课题(zc20203002)

摘　　要：肠上皮化生与胃癌密切相关,在胃癌的发病机制中起着重要作用,甚至被认为是肠型胃癌发生的惟一条件。早期识别肠上皮化生癌变的危险分层患者,对胃癌的早诊断、早治疗发挥重要作用。目前肠化生进展癌变的过程与P53、OLFM4、SOX2、CDX2、Bcl-2基因、HER-2、VEGF、MUC2、端粒酶逆转录酶、DNA甲基化等相关分子因素密切相关。文章探讨肠上皮化生癌变的相关分子进展,筛选肠上皮化生癌变的分子标志物,有助于早期胃癌的诊断及治疗。The gastric cancer is one of the malignant tumors with high mortality in our country.The lack of early diagnostic detection markers,inefficient prognostic histological indicators,limited therapeutic methods and molecular markers of effective targeted therapy are the reasons for the low 5-year survival rate.Intestinal metaplasia plays an important role in the pathogenesis of gastric cancer,and is even considered to be the only condition for the occurrence of intestinal gastric cancer.Early identification of risk stratified patients with intestinal metaplasia plays an important role in early diagnosis of gastric cancer.At present,the intestinal metaplasia progressed to gastric carcinoma is closely related to P53,OLFM4,SOX2,CDX2,Bcl-2 gene,HERB-2,VEGF,MUC2,telomeres,DNA methylation and other related molecular factors.we discuss the molecular progress of intestinal metaplasia and screening the molecular markers,That will be helpful for the diagnosis and treatment of early gastric cancer.

关 键 词：肠上皮化生 胃癌 分子标志物 

分 类 号：R574[医药卫生—消化系统] R734.2[医药卫生—内科学]