FGF23高表达与多发性骨髓瘤骨损害及肾功能不全的研究进展  

Research progress on the correlation of high FGF-23 expression with bone destruction and renal insufficiency in multiple myeloma

作　　者：刘艳琦(综述) 云雁(审校)[1] Yanqi Liu;Yan Yun(Department of Hematology,The First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010,China)

机构地区：[1]内蒙古科技大学包头医学院第一附属医院血液内科,内蒙古包头市014010

出　　处：《中国肿瘤临床》2023年第17期901-905,共5页Chinese Journal of Clinical Oncology

基　　金：内蒙古自治区高等学校科学技术研究项目(编号:202202244)资助。

摘　　要：多发性骨髓瘤(multiple myeloma,MM)是一种克隆性浆细胞异常增殖的恶性疾病,为血液系统第2位常见恶性肿瘤。目前病因尚未完全明确,多数患者伴有骨破坏、肾功能不全、贫血等临床表现,严重影响患者预后,仍不可治愈。多数MM患者的血清成纤维细胞生长因子23(fibroblast growth factor-23,FGF-23)显著升高,提示FGF-23除了参与体内钙磷调节外,还参与骨的破坏和骨髓微环境血管的形成,同时最新研究表明FGF-23的调控与铁代谢有密切的关联,其可能是促进MM疾病进展或促进相关并发症产生的重要因子,与MM预后不良相关,深入研究MM中FGF-23的调控作用有望成为临床MM靶器官损害的预后评估新的预测因子,可能为靶向治疗提供新的思路。Multiple myeloma(MM)is a malignant disease characterized by abnormal clonal plasma cell proliferation and is the second most common malignant tumor in the blood system.The exact cause of this disease remains unclear.Most patients present with clinical manifestations such as bone destruction,renal insufficiency,and anemia,which seriously affect the prognosis of patients and are still incurable.Previous studies demonstrated a significant increase in the serum fibroblast growth factor-23(FGF-23)among patients with MM.FGF-23 is not only involved in bone destruction and the formation of blood vessels in the bone marrow microenvironment but also regulates calcium and phosphorus levels in vivo.Moreover,recent studies have revealed a close relationship between FGF-23 regulation and iron metabolism.This connection could potentially play a significant role in MM progression and the development of associated complications.Moreover,it has been linked to a poor prognosis.Further studies on FGF-23 regulation in patients with MM are expected to become a new predictive factor for evaluating the prognosis of clinical target organ damage.This study may provide new insights for targeted therapy.

关 键 词：多发性骨髓瘤 成纤维细胞生长因子23 骨破坏 骨髓血管 

分 类 号：R733.3[医药卫生—肿瘤]