卵巢未成熟畸胎瘤后生长性畸胎瘤综合征一例并文献复习  

A Case of Growing Teratoma Syndrome Secondary to Ovarian Immature Teratoma and Literature Review

作　　者：万桃 俞萍源 杨永秀[2] WAN Tao;YU Ping-yuan;YANG Yong-xiu(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Department of Obstetrics and Gynecology,The First Hospital of Lanzhou University,Gansu Province Key Laboratory of Gynecological Oncology,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,730000 [2]兰州大学第一医院妇产科,甘肃省妇科肿瘤重点实验室

出　　处：《国际妇产科学杂志》2023年第5期597-600,共4页Journal of International Obstetrics and Gynecology

基　　金：兰州大学医学科研创新能力提升项目(lzuyxcx-2022-200);兰州大学第一医院院内基金(LDYYLL2022-87)。

摘　　要：生长性畸胎瘤综合征(growing teratoma syndrome,GTS)是一种发生在未成熟畸胎瘤(immature teratoma,IMT)或混合性恶性生殖细胞肿瘤患者中的罕见疾病。其特征是在手术治疗后的辅助化疗期间或化疗结束后的肿瘤标志物正常的情况下,手术残存病灶增大或出现其他部位肿块,术后病理学检查仅存在成熟畸胎瘤组织,无恶性生殖细胞。完全性手术切除是GTS治疗的首选方案,而免疫调节、化疗及射频消融术可阻止疾病进展。GTS诊断明确,但发病率低,容易误诊为恶性肿瘤复发。现报告1例卵巢IMT后GTS病例,复习相关文献,以期提高对该病的认识,丰富临床经验,减少误诊和漏诊。Growing teratoma syndrome(GTS)is a rare disease that occurs in patients with immature teratoma(IMT)or mixed malignant germ cell tumors.Its characteristics are that during adjuvant chemotherapy or after chemotherapy after surgery treatment,the tumor markers are normal,the residual lesions of surgery are enlarged or other masses appear,and the postoperative pathological examination only shows mature teratoma tissue,without malignant germ cells.Complete surgical resection is the preferred option for the treatment for GTS,while immunoregulation,chemotherapy,and radiofrequency can stop the disease progression.The diagnosis of this disease is clear,but the incidence is low,and it is easy to be misdiagnosed as malignant tumor recurrence.A case of ovarian GTS after IMT is reported.Relevant literature is reviewed to improve the understanding of the disease,enrich clinical experience,and reduce misdiagnosis and underdiagnosis.

关 键 词：畸胎瘤 复发 诊断 生长性畸胎瘤综合征 未成熟畸胎瘤 

分 类 号：R737.31[医药卫生—肿瘤]