Evolution of p53 pathway-related genes provides insights into anticancer mechanisms of natural longevity in cetaceans  

作　　者：Xing Liu Fei Yang Yi Li Zhen-Peng Yu Xin Huang Lin-Xia Sun Wen-Hua Ren Guang Yang Shi-Xia Xu 

机构地区：[1]Jiangsu Key Laboratory for Biodiversity and Biotechnology,College of Life Sciences,Nanjing Normal University,Nanjing,Jiangsu 210023,China

出　　处：《Zoological Research》2023年第5期947-949,共3页动物学研究（英文）

基　　金：supported by the National Key Program of Research and Development,Ministry of Science and Technology of China (2022YFF1301600);National Natural Science Foundation of China (32070409,32270453 to S.X.X.);Priority Academic Program Development of Jiangsu Higher Education Institutions to G.Y.and S.X.X.;Qing Lan Project of Jiangsu Province to S.X.X.

摘　　要：DEAR EDITOR,Despite the generally increased cancer risk in large,long-lived organisms,cetaceans,among the largest and longest-living mammals,appear to possess a counteracting mechanism.Nevertheless,the genetic basis underlying this mechanism remains poorly understood.The p53 pathway serves as an ideal target for studying the mechanisms behind cancer resistance,as most cancer types have evolved strategies to circumvent its suppressive functions.

关 键 词：MECHANISM P53 MECHANISMS 

分 类 号：Q953[生物学—动物学]