血清趋化素、网膜素-1水平与缺血性脑血管病颈动脉狭窄的相关性  

Correlation analysis between serum Chemerin and Omentin-1 levels and carotid artery stenosis in ICVD patients

作　　者：张乐国[1] 贾建普[1] 王丽轩[2] 洪震[3] 张俊玲[2] 朱翠敏[4] ZHANG Leguo;JIA Jianpu;WANG Lixuan;HONG Zhen;ZHANG Junling;ZHU Cuimin(Department 8 of Neurology,Cangzhou Central Hospital,Cangzhou,Hebei 061001,China;Department 2 of Neurology,Cangzhou Central Hospital,Cangzhou,Hebei 061001,China;Department of Neurovascular Intervention,Cangzhou Central Hospital,Cangzhou,Hebei 061001,China;Department 5 of Pediatrics,Cangzhou Central Hospital,Cangzhou,Hebei 061001,China)

机构地区：[1]沧州市中心医院神经内八科,河北沧州061001 [2]沧州市中心医院神经内二科,河北沧州061001 [3]沧州市中心医院神经血管介入科,河北沧州061001 [4]沧州市中心医院儿内五科,河北沧州061001

出　　处：《安徽医药》2023年第11期2194-2198,共5页Anhui Medical and Pharmaceutical Journal

基　　金：河北省医学科学研究课题计划(20211278)。

摘　　要：目的探究血清趋化素、网膜素-1水平与缺血性脑血管病(ICVD)病人颈动脉狭窄的相关性。方法选取2017年2月至2020年1月在沧州市中心医院诊治ICVD病人60例为研究对象,并选择同期30例健康体检者为对照组。收集所有病人的一般临床资料。ICVD病人均接受数字减影血管造影(DSA)并计算动脉狭窄率,并将病人分为轻度狭窄组和中重度狭窄组,采用双抗体夹心免疫吸附法检测病人血清趋化素、网膜素-1水平。检测三组病人的实验室指标,并采用Pearson相关性分析趋化素、网膜素-1水平与实验室指标的关系。ROC曲线分析趋化素、网膜素-1对病人发生中重度狭窄的评估价值。结果与对照组相比,轻度狭窄组和中重度狭窄组病人血清趋化素水平依次升高,而网膜素-1水平依次下降,均差异有统计学意义(P<0.05)。实验室指标检测结果显示,与对照组相比,轻度狭窄组和中重度狭窄组病人收缩压(SBP)、三酰甘油(TG)、空腹血糖(FPG)和C反应蛋白(CRP)水平均显著升高(P<0.05),而高密度脂蛋白胆固醇(HDL-C)水平显著降低(P<0.05)。与轻度狭窄组病人相比,中重度狭窄组病人SBP、TG、FPG、CRP和低密度脂蛋白胆固醇(LDL-C)显著升高,而HDL-C水平显著降低(P<0.05)。Pearson相关性分析显示,趋化素与SBP、CRP和LDL-C呈显著正相关(P<0.05),网膜素-1与SBP、CRP呈显著负相关(P<0.05),与HDL-C呈显著正相关(P<0.05)。ROC曲线分析趋化素、网膜素-1对病人发生中重度狭窄的评估价值曲线下面积(AUC)分别为0.86、0.83,灵敏度分别为80.00%、80.00%,特异度分别为83.30%、76.70%。结论血清趋化素、网膜素-1水平的异常表达与ICVD病人颈动脉狭窄存在一定的关系,且对疾病的发展评估有重要意义。Objective To explore the correlation between serum Chemerin and Omentin-1 levels and carotid artery stenosis in patients with ischemic cerebrovascular disease(ICVD).Methods Sixty patients with ICVD in Cangzhou Central Hospital from February 2017 to January 2020 were selected as the research subjects,and 30 healthy subjects were selected as the control group during the same period.The general clinical data of all patients were collected.ICVD patients received digital subtraction angiography(DSA)and the arterial stenosis rate was calculated.The patients were divided into mild stenosis group and moderate to severe stenosis group,the serum Chemerin and Omentin-1 levels of the patients were detected by double antibody sandwich immunosorbent method.The laboratory indicators of patients in the three groups were tested,and the Pearson correlation was used to analyze the relationship between the levels of Chemerin and Omentin-1 and the laboratory indicators.ROC curve was used to analyze the evaluation value of Chemerin and Omentin-1 in patients with moderate to severe stenosis.Results Compared with the control group,the serum Chemerin level of patients in the mild stenosis group and the moderate to severe stenosis group increased sequentially,while the Omentin-1 level decreased sequentially,and the difference was significant(P<0.05).The laboratory index test results showed that compared with the control group,the levels of systolic blood pressure(SBP),triglycerides(TG),fasting plasma glucose(FPG),and C-reactive protein(CRP)patients in the mild stenosis group and the moderate to severe stenosis group were significantly increased(P<0.05),while the level of high-density lipoprotein cholesterol(HDL-C)was significantly reduced(P<0.05).Compared with patients in the mild stenosis group,the SBP,TG,FPG,CRP,and low-density lipoprotein cholesterol(LDL-C)in the moderate-to-severe stenosis group were significantly increased,while the level of HDL-C was significantly decreased(P<0.05).Pearson correlation analysis showed that Chemerin w

关 键 词：颈动脉狭窄 趋化素 网膜素-1 缺血性脑血管病 数字减影血管造影 

分 类 号：R743[医药卫生—神经病学与精神病学]