小剂量沙利度胺联合BD方案在多发性骨髓瘤中应用效果观察  

The Effect of Low-dose Thalidomide in Combination with BD Regimen in Multiple Myeloma

作　　者：郭娜 郭侃 Guo Na;Guo Kan(Yongcheng People’s Hospital,Yongcheng,Henan,476600,China)

机构地区：[1]永城市人民医院,河南永城476600

出　　处：《黑龙江医学》2023年第19期2336-2338,共3页Heilongjiang Medical Journal

摘　　要：目的:探讨小剂量沙利度胺联合BD方案(地塞米松、硼替佐米)在多发性骨髓瘤(Multiple myeloma,MM)中应用效果。方法:选取2017年2月—2020年5月永城市人民医院收治的86例MM患者作为研究对象,随机分为两组,每组各43例。对照组采取BD方案,研究组在对照组基础上加用小剂量沙利度胺。统计两组患者治疗效果、毒副反应发生率,治疗前后免疫抑制相关因子(IL-6、IL-17、TGF-β1)水平。结果:研究组总有效率(86.05%)高于对照组(67.44%),差异有统计学意义(χ^(2)=4.170,P<0.05)。两组患者毒副反应发生率比较,差异无统计学意义(χ^(2)=0.608、0.231、0.567、0.281、0.261,P>0.05)。IL-6、IL-17、TGF-β1治疗后较治疗前降低,差异有统计学意义(t=8.902、9.682、6.331,P<0.05)。结论:联合采取小剂量沙利度胺及BD方案治疗MM效果显著,可有效下调血清IL-6、IL-17、TGF-β1水平,减轻机体免疫抑制,且具有安全性。Objective:To investigate the effect of low-dose thalidomide in combination with BD regimen(dexamethasone,bortezomib)in multiple myeloma(MM).Methods:86 patients with MM in the hospital from February 2017 to May 2020 were se⁃lected as the study population and randomly divided into two groups,with 43 cases in each group.The control group took BD regi⁃men,and the study group added a small dose of thalidomide on top of the control group.The treatment effect,incidence of toxic side effects,levels of immunosuppression-related factors(IL-6,IL-17,TGF-β1)before and after treatment were counted in both groups.Results:The total effective rate of the study group(86.05%)was higher than that of the control group(67.44%),and the difference was statistically significant(χ^(2)=4.170,P<0.05).There was no statistically significant difference in the incidence of toxic side effects between the two groups(χ^(2)=0.608,0.231,0.567,0.281,0.261,P>0.05).IL-6,IL-17,and TGF-β1 decreased after treatment compared to before treatment,with statistically significant differences(t=8.902,9.682,6.331,P<0.05).Conclusion:The combination of low-dose thalidomide and BD regimen is effective in treating MM,which can effectively downregulate serum IL-6,IL-17 and TGF-β1 levels and reduce the body’s immunosuppression,and is safe.

关 键 词：沙利度胺 地塞米松 硼替佐米 多发性骨髓瘤 

分 类 号：R738.1[医药卫生—肿瘤]