Effects of obstructive sleep apnea on retinal microvasculature  

作　　者：Müjdat Karabulut Semai Bek Sinem Karabulut Aylin Karalezli Gülnihal Kutlu 

机构地区：[1]Ophthalmology Department,Mugla Sitki Kocman University Training and Research Hospital,Mugla 48300,Türkiye [2]Neurology Department,Mugla Sitki Kocman University Faculty of Medicine,Mugla 48300,Türkiye [3]Ophthalmology Department,Mugla Sitki Kocman University Faculty of Medicine,Mugla 48300,Türkiye

出　　处：《International Journal of Ophthalmology(English edition)》2023年第10期1670-1675,共6页国际眼科杂志（英文版）

摘　　要：AIM:To detect retinal microvascular variations in obstructive sleep apnea syndrome patients.METHODS:This prospective,observational case-control study included healthy controls and patients with mild,moderate,and severe obstructive sleep apnea syndrome.Vascular parameters,foveal avascular area,and flow areas in macula-centered,6.00×6.00 mm2 scan size optical coherence tomography angiography images were compared.RESULTS:The control group had the highest whole image,parafoveal,and perifoveal vessel density among the groups in both superficial and the deep capillary plexus(all P<0.05).Rapid eye movement sleep apnoea-hypopnoea index was reversely correlated with whole(Rho=-0.195,P=0.034),parafoveal(Rho=-0.242,P=0.008),perifoveal(Rho=-0.187,P=0.045)vessel density in the superficial capillary plexus,and whole(Rho=-0.186,P=0.046),parafoveal(Rho=-0.260,P=0.004),perifoveal(Rho=-0.189,P=0.043)vessel density in the deep capillary plexus,though the mean and non-rapid eye movement sleep apnoeahypopnoea index related with only parafoveal vessel density in the superficial capillary plexus(Rho=-0.213,P=0.020;Rho=-0.191,P=0.038)and the deep capillary plexus(Rho=-0.254,P=0.005;Rho=-0.194,P=0.035).CONCLUSION:This study shows decreased vessel density and its reverse correlation with the apnoea-hypopnoea index in patients with obstructive sleep apnea syndrome.

关 键 词：apnoea-hypopnoea index deep capillary plexus obstructive sleep apnea superficial capillary plexus vessel density retinal microvasculature 

分 类 号：R774.1[医药卫生—眼科] R766[医药卫生—临床医学]