肽锌络合物促锌吸收机制研究进展  

Progress in Zinc Absorption Mechanism of Peptide-Zinc Complex

作　　者：王思怡 杨晰茗 王震宇 杜明 程述震 WANG Siyi;YANG Ximing;WANG Zhenyu;DU Ming;CHENG Shuzhen(National Engineering Research Center of Seafood,School of Food Science and Technology,Dalian Polytechnic University,Dalian 116034,Liaoning,China)

机构地区：[1]大连工业大学食品学院国家海洋食品工程技术研究中心,辽宁大连116034

出　　处：《食品研究与开发》2023年第19期172-179,共8页Food Research and Development

基　　金：国家自然科学基金重点项目(32130085);国家自然科学基金青年基金项目(32202021);辽宁省教育厅高校基本科研项目(LJKQZ20222379)。

摘　　要：锌是人体必需的微量元素,具有广泛的生理功能,锌缺乏症及其导致的营养不良是我国目前重要的营养健康问题之一。肽锌络合物作为一种新型高效补锌物质倍受关注,然而,其吸收形式和机制尚未被完全阐明,且与锌具有结合能力的多肽结构特征未被明晰。就肽锌络合物的结构稳定性和吸收特异性两大方面论述其促锌吸收的机理,同时对影响肽锌络合物结构稳定性的因素进行综述,阐明与锌具有结合能力的多肽结构特征及对锌离子的保护作用。进一步采用多种吸收模型分析多肽锌络合物在小肠上皮细胞中的吸收与转运机制,为开发新型高效肽锌络合物型补充剂提供理论基础。Zinc is an essential trace element for the human body and has a wide range of physiological functions.Zinc deficiency and the resulted malnutrition are the major nutritional health problems in China.The peptide-zinc complex as a new effective zinc supplement has attracted much attention.However,its absorption form and mechanism have not been fully clarified,and the structures of the peptides capable of binding to zinc remain to be characterized.The mechanism of zinc absorption was discussed in terms of the structural stability and absorption specificity of peptide-zinc complexes.The factors affecting the structural stability of peptide-zinc complexes were reviewed.The structural characteristics of peptides capable of binding to zinc and the protective effects of the peptides on zinc ions were expounded.Furthermore,multiple absorption models were employed to analyze the absorption and transport mechanisms of peptide-zinc complexes in intestinal epithelial cells,which provided a theoretical basis for the development of novel efficient peptide-zinc complexes as zinc supplements.

关 键 词：锌补充剂 肽锌络合物 吸收机制 多肽转运受体 锌离子转运受体 

分 类 号：TS202.3[轻工技术与工程—食品科学]