升清降浊汤联合奥美拉唑治疗胃食管反流病的疗效及对血清GAS、胃动素水平的影响  

Effect of Shengqing Jiangturbidity Decoction combined with omeprazole on gastroesophageal reflux disease and serum gastrin and motilin levels

作　　者：密亚琦 王璐 单连美 MI Ya-qi;WANG Lu;SHAN Lian-mei(Department of Gastroenterology,Qingdao Fifth People's Hospital,Qingdao Shandong 266002,China)

机构地区：[1]青岛市第五人民医院消化内科,山东青岛266002

出　　处：《临床和实验医学杂志》2023年第18期1950-1953,共4页Journal of Clinical and Experimental Medicine

基　　金：山东省卫健委科研基金项目(编号:20201588)。

摘　　要：目的探讨升清降浊汤联合奥美拉唑治疗胃食管反流病(GERD)的疗效及对血清胃泌素、胃动素水平的影响。方法前瞻性选择2020年6月至2022年6月在青岛市第五人民医院进行治疗的90例GERD患者作为研究对象,按照随机数字表法分为观察组(n=45)和对照组(n=45)。对照组常规给予奥美拉唑进行治疗,观察组在此基础上加用升清降浊汤治疗,两组均治疗8周。比较两组疗效、治疗前后中医症候积分变化、肠胃激素水平、生活质量以及不良反应和复发情况。结果观察组总有效率为95.56%,显著高于对照组(80.00%),差异有统计学意义(P<0.05)。治疗8周后,两组中医证候积分均较治疗前下降,且观察组中医证候积分均低于对照组,差异均有统计学意义(P<0.05)。治疗8周后,两组胃泌素、胃动素水平均较治疗前升高,且观察组胃泌素、胃动素水平均显著高于对照组,差异均有统计学意义(P<0.05)。治疗8周后,两组生活质量各维度评分均较治疗前升高,且观察组生活质量各维度评分均显著高于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05);观察组复发率为8.89%,显著低于对照组(26.67%),差异有统计学意义(P<0.05)。结论升清降浊汤联合奥美拉唑治疗GERD的疗效显著,可明显缓解临床相关症状,调节胃肠激素水平,提高患者生活质量,降低复发率,安全性高,值得临床推广。Objective To investigate the efficacy of Shengqing Jiangturbidity Decoction combined with omeprazole in the treatment of gastroesophageal reflux disease(GERD)and the effects on serum gastrin and motilin levels.Methods A total of 90 GERD patients treated in Qingdao Fifth People's Hospital from June 2020 to June 2022 were prospectively selected as research objects and divided into observation group(n=45)and control group(n=45)according to the random number table method.The control group was treated with omeprazole,and the observation group was treated with Shengqing Jiangturbid decoction on the basis of control group.Both groups were treated for 8 weeks.The efficacy,the change of TCM syndrome score before and after treatment,gastrointestinal hormone level,quality of life,adverse reactions and recurrence were compared between the two groups.Results The total effective rate of observation group was 95.56%,which was significantly higher than that of control group(80.00%),the difference was statistically significant(P<0.05).After 8 weeks of treatment,the TCM syndrome scores of both groups were lower than those before treatment,and the TCM syndrome scores of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).After 8 weeks of treatment,the levels of gastrin and motilin in both groups were higher than those before treatment,and the average levels of gastrin and motilin in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).After 8 weeks of treatment,the scores of all dimensions of quality of life in both groups were higher than those before treatment,and the scores of all dimensions of quality of life in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05),the recurrence rate

关 键 词：升清降浊汤 奥美拉唑 胃食管反流病 胃泌素 胃动素 

分 类 号：R571[医药卫生—消化系统]