甲胎蛋白在胃肝样腺癌中的作用机制及诊断预后研究进展  

Progress on the role mechanism,diagnostic value and prognosis of alpha fetoprotein in hepatoid adenocarcinoma of the stomach

作　　者：兰青 熊枝繁 杨盛力[2] Lan Qing;Xiong Zhifan;Yang Shengli(Department of Gastroenterology,Liyuan Hospital of Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430077,China;Cancer Center of Xiehe Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属梨园医院消化内科,武汉430077 [2]华中科技大学同济医学院附属协和医院肿瘤中心,武汉430022

出　　处：《中华普通外科学文献（电子版）》2023年第5期376-379,共4页Chinese Archives of General Surgery(Electronic Edition)

摘　　要：胃肝样腺癌(HAS)是一种罕见的恶性肿瘤,属于胃癌的特殊亚型,兼具腺癌和肝细胞癌样分化特征,且大部分患者血清甲胎蛋白(AFP)升高。作为肝癌的肿瘤标志物,AFP被广泛应用于临床,但其对于HAS的作用和价值还不明确。为进一步加深AFP在HAS中的认识并了解其临床意义,现就AFP在该病中的作用机制、诊断价值及预后关系等方面进行综述,以帮助临床医师准确诊治。Hepatoid adenocarcinoma of the stomach(HAS)is a special subtype of gastric cancer,which is a rare malignant tumor with both adenocarcinoma and hepatocellular carcinoma-like differentiation,and most patients have elevated serum alpha fetoprotein(AFP).However,the value of AFP in HAS is still unclear.In order to further deepen the comprehensive understanding of AFP in HAS and to understand its clinical significance,the role mechanism,diagnostic value and prognosis of AFP are reviewed for accurate diagnosis and treatment of HAS in clinics.

关 键 词：胃肝样腺癌 甲胎蛋白 诊断 预后 

分 类 号：R735.7[医药卫生—肿瘤]