重症急性胰腺炎合并腹腔感染外周血ICAM-1及miR-22-3p、miR-21-3p表达及其预测价值  

Expressions of ICAM-1,miR-22-3p and miR-21-3p in peripheral blood of severe acute pancreatitis patients complicated with abdominal infection and their predictive values

作　　者：张云祥 吴琴华 吴玉塘[1] 陈志钊[1] 蔡凯晋[1] ZHANG Yun-xiang;WU Qin-hua;WU Yu-tang;CHEN Zhi-zhao;CAI Kai-jin(The Second Affiliated Hospital of Fujian Medical University,Quanzhou,Fujian 362000,China)

机构地区：[1]福建医科大学附属第二医院急诊科,福建泉州362000

出　　处：《中华医院感染学杂志》2023年第17期2639-2642,共4页Chinese Journal of Nosocomiology

基　　金：福建省自然科学基金资助项目(2020J01122610)。

摘　　要：目的分析血清细胞黏附分子-1(ICAM-1)、外周血微小核糖核酸-22-3p(miR-22-3p)、miR-21-3p表达对重症急性胰腺炎患者合并腹腔感染的预测价值.方法选择2021年1月-2022年8月福建医科大学附属第二医院收治的90例重症急性胰腺炎合并腹腔感染患者为感染组,同期102例单纯重症急性胰腺炎患者为未感染组,统计两组外周血ICAM-1、miR-22-3p、miR-21-3p表达水平,采用受试者工作特征(ROC)曲线分析预测重症急性胰腺炎患者合并腹腔感染的临床价值,并比较住院期间重症急性胰腺炎合并腹腔感染不同预后患者表达水平.结果感染组患者外周血ICAM-1、miR-22-3p、miR-21-3p表达水平高于未感染组(P<0.05);三指标联合检测预测重症急性胰腺炎患者腹腔感染的曲线下面积(AUC)为0.923、敏感度为92.22%、特异度为81.37%;死亡组患者三指标表达水平高于存活组(P<0.05).结论外周血ICAM-1、miR-22-3p、miR-21-3p对重症急性胰腺炎患者合并腹腔感染具有较好的预测价值,且可对患者预后产生影响.OBJECTIVE To observe the expressions of serum cell adhesion molecule-1(ICAM-1),peripheral blood microrna-22-3p(miR-22-3p)and microrna-21-3p(miR-21-3p)in the severe acute pancreatitis patients complicated with abdominal infection.METHODS A total of 9O severe acute pancreatitis patients who were complicated with abdominal infection and treated in the Second Affiliated Hospital of Fujian Medical University from Jan 2021 to Aug 2022 were assigned as the infection group,meanwhile,102 patients with simple severe acute pancreatitis were chosen as the no infection group.The expression levels of peripheral blood ICAM-1,miR-22-3p and miR-21-3p were statistically analyzed,the values of the indexes in prediction of abdominal infection in the severe acute pancreatitis patients were analyzed by means of receiver operating characteristic(ROC)curve,and the expression levels of the indexes were observed and compared among the patients with different treatment outcomes.RESULTS The expression levels of peripheral blood ICAM-1,miR-22-3p and miR-21-3p of the infection group were higher than those of the no infection group(P<0.05).The area under curve(AUC)of the joint detection of the three indexes was O.923 in prediction of abdominal infection in the patients with severe acute pancreatitis,with the sensitivity 92.22%,the specificity 81.37%;the expression levels of the three indexes of the death group were higher than those of the survival group(P<0.05).CONCLUSION The peripheral blood ICAM-1,miR-22-3p and miR-21-3p have high values in prediction of the complicated abdominal infection in the patients with severe acute pancreatitis and may affect the prognosis of the patients.

关 键 词：重症急性胰腺炎 腹腔感染 细胞黏附分子-1 微小核糖核酸-22-3p 微小核糖核酸-21-3p 预测价值 受试者工作特征曲线 

分 类 号：R576[医药卫生—消化系统]