工业规模的过渡金属催化不对称氢化研究进展  

Progress in Industrial-scale Transition Metal Catalytic Asymmetric Hydrogenation

作　　者：杨泽慧 黄炼 宋定国[1] 凌飞[1] 钟为慧[1] YANG Zehui;HUANG Lian;SONG Dingguo;LING Fei;ZHONG Weihui(College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou 310014)

机构地区：[1]浙江工业大学药学院,浙江杭州310014

出　　处：《中国医药工业杂志》2023年第6期835-858,共24页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金项目(22178315、21978271)。

摘　　要：过渡金属催化不饱和化合物的不对称氢化是获得手性化合物较经济、较有效的途径。经过数十年卓有成效的不对称催化基础研究,以过渡金属催化不对称氢化为核心技术,成功实现了许多手性化合物,如手性氨基酸、手性醇、手性胺、手性羧酸等的工业规模制备。该文主要概述近20年来工业规模的过渡金属催化不对称氢化含有碳-氧双键(C=O)、碳-碳双键(C=C)以及碳-氮双键(C=N)的不饱和化合物以构建相应的手性药物或活性关键中间体的方法。The transition metal complexes-catalyzed the asymmetric hydrogenation of unsaturated compounds is one of the most economical and efficient ways to obtain chiral compounds.After decades of efficient research on asymmetric catalysis,with transition metal catalytic asymmetric hydrogenation as the core technology,many chiral compounds,such as chiral amino acids,chiral alcohols,chiral amines,and chiral carboxylic acids,have been successfully prepared on industrials scale.This paper mainly provides an overview of methods for the industrial-scale asymmetric catalytic hydrogenation reduction of unsaturated compounds containing carbon-oxygen double bond(C=O),carboncarbon double bond(C=C) and carbon-nitrogen double bond(C=N) in order to build the corresponding chiral drugs or active key intermediates.

关 键 词：过渡金属催化 不对称氢化 不饱和化合物 手性药物 工业规模 

分 类 号：TQ460.6[化学工程—制药化工]