傅克烷基化法制备β-苯乙醇的工艺研究  

Study on the Preparation ofβ-Phenylethanol by Friedel-Crafts Alkylation

作　　者：赵松芳 刘永新 张奥文 刘景辉 胡国勤[2] ZHAO Songfang;LIU Yongxin;ZHANG Aowen;LIU Jinghui;HU Guoqin(Sanmenxia Aoke Chemical Co.,Ltd.,Sanmenxia 472123,China;College of Chemical Engineering,Zhengzhou University,Zhengzhou 450001,China)

机构地区：[1]三门峡奥科化工有限公司,河南三门峡472123 [2]郑州大学化工学院,河南郑州450001

出　　处：《河南化工》2023年第10期19-22,26,共5页Henan Chemical Industry

基　　金：2022年度郑州大学大学生创新创业训练计划项目(2022cxcy110)。

摘　　要：通过傅克烷基化法制备标题化合物,通过单因素和正交试验,考察了反应物物质的量比、反应温度、反应时间等对收率的影响,最终确定合成标题化合物的最优条件为:n(苯)∶n(三氯化铝)∶n(环氧乙烷)=2.4∶0.3∶0.2,加料采用滴加方式[滴加混合液中m(苯)∶m(环氧乙烷)=12∶1],滴加温度6~9℃,反应温度6~12℃,反应时间80 min。对β-苯乙醇粗产品一次蒸馏含量可达98.31%。该方法成本低,工艺流程简单,适合中小企业规模化生产。The title compound is prepared by Friedel-Crafts alkylation.The effects of molar ratio of reactants,reaction temperature and reaction time on the yield are investigated by single factor and orthogonal experiments.Finally,the optimal conditions for the synthesis of the title compound are determined as follows:n(benzene)∶n(aluminum trichloride)∶n(ethylene oxide)=2.4∶0.3∶0.2,dropping method(m(benzene)∶m(ethylene oxide)=12∶1),dropping temperature of 6~9℃,reaction temperature of 6~12℃,reaction time of 80 min.The content of crude product ofβ-phenylethanol can reach 98.31%by one distillation.This method is low cost,simple process,suitable for large-scale production of small and medium-sized enterprises.

关 键 词：Β-苯乙醇 环氧乙烷 傅克烷基化法 正交试验 工艺优化 

分 类 号：TQ233[化学工程—有机化工]