TTF-1、CDK4、EGFR在非小细胞肺癌组织中的表达及与临床病理特征的相关分析  

Expression of TTF-1,CDK4 and EGFR in non-small cell lung cancer and their correlation with clinicopathological characteristics

作　　者：冷茹冰 徐衡 李娜[3,4] LENG Ru-bing;XU Heng;LI Na(Department of Pathology,Zhumadian Central Hospital,Zhumadian,Henan 463000,China;Department of Neurology,Zhumadian Central Hospital Zhumadian,Henan 463000,China;Department of Pathology,the Third Affiliated Hospital of Xinxiang Medical College,Xinxiang,Henan 453003,China;Department of Pathology,School of Basic Medicine,Xinxiang Medical College,Xinxiang,Henan 453003,China)

机构地区：[1]驻马店市中心医院病理科,河南驻马店463000 [2]驻马店市中心医院神经内科,河南驻马店463000 [3]新乡医学院第三附属医院病理科,河南新乡453003 [4]新乡医学院基础医学院病理学系,河南新乡453003

出　　处：《医药论坛杂志》2023年第16期30-34,共5页Journal of Medical Forum

摘　　要：目的 探讨甲状腺转录因子1(TTF-1)、细胞周期蛋白依赖性激酶4(CDK4)、表皮生长因子受体(EGFR)在非小细胞肺癌(NSCLC)组织中的表达,并分析其与临床病理特征的关系。方法 选取2021年1月—2022年10月在驻马店市中心医院诊治的NSCLC患者115例,检测癌组织和癌旁组织TTF-1、CDK4、EGFR表达,并分析癌组织TTF-1、CDK4、EGFR表达与年龄、性别、肿瘤直径、肿瘤位置、肿瘤分期、分化程度、淋巴结转移、吸烟等临床病理特征的关系。结果 NSCLC患者癌组织TTF-1阳性率(58.26%vs 10.43%)、CDK4阳性率(92.17%vs 84.35%)、EGFR阳性率(64.35%vs 6.09%)明显高于癌旁组织(P<0.05)。NSCLC患者癌组织TTF-1阳性表达与年龄、性别、肿瘤直径、肿瘤位置、吸烟无关(P>0.05),与肿瘤分期、分化程度、淋巴结转移有关(P<0.05);NSCLC患者癌组织EGFR阳性表达与年龄、性别、肿瘤直径、肿瘤位置、吸烟无关(P>0.05),与肿瘤分期、分化程度、淋巴结转移有关(P<0.05);NSCLC患者癌组织CDK4阳性表达与年龄、性别、肿瘤直径、肿瘤位置、淋巴结转移、吸烟无关(P>0.05),与肿瘤分期、分化程度有关(P<0.05)。结论 TTF-1、CDK4、EGFR在NSCLC患者癌组织呈高表达,TTF-1、EGFR与NSCLC的发生、发展以及转移有关,CDK4与NSCLC的发生以及发展有关。Objective To investigate the expression of thyroid transcription factor 1(TTF-1),cyclin dependent kinase 4(CDK4)and epidermal growth factor receptor(EGFR)in non-small cell lung cancer(NSCLC),and analyze their relationship with clinicopathological characteristics.Methods Totally 115 NSCLC patients diagnosed and treated at Zhumadian Central Hospital from January 2021 to October 2022 were selected to detect the expression of TTF-1,CDK4,and EGFR in cancer tissue and adjacent tissues.The relationship between TTF-1,CDK4,and EGFR expression in cancer tissue and clinical pathological characteristics such as age,gender,tumor diameter,tumor location,tumor stage,differentiation,lymph node metastasis,smoking was analyzed.Results The positive rates of TTF-1(58.26%vs 10.43%),CDK4(92.17%vs 84.35%),and EGFR(64.35%vs 6.09%)in cancer tissues of NSCLC patients were significantly higher than those in adjacent tissues(P<0.05).The positive expression of TTF-1 in cancer tissue of NSCLC patients was not related to age,gender,tumor diameter,tumor location,smoking(P<0.05),but was related to tumor stage,differentiation,and lymph node metastasis(P<0.05);The positive expression of EGFR in cancer tissue of NSCLC patients was not related to age,gender,tumor diameter,tumor location,smoking(P<0.05),but was related to tumor stage,differentiation,and lymph node metastasis(P<0.05);The positive expression of CDK4 in cancer tissue of NSCLC patients was not related to age,gender,tumor diameter,tumor location,lymph node metastasis,smoking(P<0.05),but was related to tumor stage and differentiation degree(P<0.05).Conclusion TTF-1,CDK4,and EGFR are highly expressed in cancer tissues of NSCLC patients.TTF-1,EGFR are associated with the occurrence,development,and metastasis of NSCLC,while CDK4 is associated with the occurrence and development of NSCLC.

关 键 词：甲状腺转录因子1 细胞周期蛋白依赖性激酶4 表皮生长因子受体 非小细胞肺癌 临床病理特征 组织 

分 类 号：R734.2[医药卫生—肿瘤]