奥曲肽不同用药方式治疗急性胰腺炎的效果分析  

Analysis of the Effect of Different Mode of Octreotide Administration in the Treatment of Acute Pancreatitis

作　　者：黄蓓 臧夫宁 沙跃[2] HUANG Bei;ZANG Funing;SHA Yue(Department of Spleen and Stomach,Pizhou Hospital of Traditional Chinese Medicine,Pizhou,Jiangsu Province,221300 China;Department of Cardiovascular Medicine I,Pizhou Hospital of Traditional Chinese Medicine,Pizhou,Jiangsu Province,221300 China)

机构地区：[1]邳州市中医院脾胃病科,江苏邳州221300 [2]邳州市中医院心血管内一科,江苏邳州221300

出　　处：《系统医学》2023年第15期67-70,共4页Systems Medicine

基　　金：江苏省中医药科技发展计划项目(YB201949)。

摘　　要：目的研究奥曲肽不同用药方式治疗急性胰腺炎(acute pancreatitis,AP)的临床效果影响。方法选择2020年1月—2023年2月在邳州市中医院治疗的76例AP患者为研究对象,将其以随机数表法分为两组,每组38例,对照组在对症治疗基础上予以奥曲肽静脉滴注治疗,观察组在对症治疗基础上予以奥曲肽(药物与对照组一致)微量注射液泵给药。对比两组疗效、症状恢复时间、住院时间、炎症因子水平、低血糖及其他并发症发生率。结果观察组总有效率为94.74%,高于对照组的78.95%,差异有统计学意义(χ^(2)=4.145,P<0.05)。观察组血尿淀粉酶水平复常、白细胞水平复常、血糖水平复常、症状消失及住院时间均短于对照组,差异有统计学意义(P<0.05)。观察组C反应蛋白、白介素-6水平略低于对照组,但差异无统计学意义(P>0.05)。观察组低血糖发生率为5.26%,其他并发症发生率为5.26%,均低于对照组,差异有统计学意义(χ^(2)=5.208、4.145,P<0.05)。结论奥曲肽不同用药方式治疗AP均可有效减轻患者机体炎症反应,但微量输液泵输注治疗疗效更好,患者症状恢复时间更短,低血糖等并发症发生率更低。Objective To study the impact of clinical effects of different dosing modes of octreotide in the treatment of acute pancreatitis(AP).Methods From January 2020 to February 2023,76 patients with AP treated in Pizhou Hospital of Traditional Chinese Medicine were selected as the research objects,and they were divided into two groups by random number table method,with 38 cases in each group.The control group was treated with octreotide intravenous drip on the basis of symptomatic treatment,and the observation group was treated with octreotide(drug consistent with the control group)microinjection pump on the basis of symptomatic treatment.The efficacy,symptom recovery time,hospitalization time,inflammatory factor level,hypoglycemia and other complications were compared between the two groups.Results The total effective rate of the observation group(94.74%)was higher than that of the control group(78.95%),and the difference was statistically significant(χ^(2)=4.145,P<0.05).The recovery of blood and urine amylase level,white blood cell level,blood glucose level,symptom disappearance and hospitalization time in the observation group were shorter than those in the control group,the differences were statistically significant(P<0.05).The levels of C-reactive protein and interleukin-6 in the observation group were slightly lower than those in the control group,but the differences were not statistically significant(P>0.05).The incidence of hypoglycemia in the observation group was 5.26%,and the incidence of other complications was 5.26%,which were lower than those in the control group,the dif ferences were statistically significant(χ^(2)=5.208,4.145,P<0.05).Conclusion The different dosing modes of octreotide in the treatment of AP can effectively reduce the inflammatory response of the patient's organism.However,the efficacy of micro infusion pump infusion treatment is better,the recovery time of patients'symptoms is shorter,and the incidence of complications such as hypoglycemia is lower.

关 键 词：奥曲肽 急性胰腺炎 低血糖 炎症因子 并发症 

分 类 号：R576[医药卫生—消化系统]