利那洛肽联合PEG对便秘患者结肠镜检查前肠道准备的影响  

Effect of linalotide combined with PEG on intestinal preparation beforecolonoscopy in patients with constipation

作　　者：曾杰[1] 古赛[1] ZENG Jie;GU Sai(Department of Gastroenterology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院消化内科,重庆400016

出　　处：《现代医药卫生》2023年第19期3268-3272,共5页Journal of Modern Medicine & Health

摘　　要：目的 探讨利那洛肽联合复方聚乙二醇电解质散(PEG)对便秘患者结肠镜检查前肠道准备的影响。方法 选取2022年1-12月该院行结肠镜检查患者175例,其中对照组58例,研究A组59例,研究B组58例。比较3组波士顿肠道准备评分量表(BBPS)评分、不良反应发生率、重复意愿、肠道准备满意度及病变检出率。结果 3组BBPS总评分比较,差异无统计学意义(P>0.05)。研究B组左半结肠BBPS评分与对照组比较,差异无统计学意义(P>0.05),但与研究A组比较,差异有统计学意义(P<0.05)。3组病变检出率比较,差异无统计学意义(P>0.05)。对照组不良反应(腹痛、乏力除外)发生率高于研究A组、研究B组,差异有统计学意义(P<0.05),而研究A组与研究B组比较,差异无统计学意义(P>0.05)。研究A组、研究B组肠道准备满意度及重复意愿高于对照组,差异有统计学意义(P<0.05),而研究A组与研究B组比较,差异无统计学意义(P>0.05)。结论 针对肠道准备比较困难的便秘患者,利那洛肽联合PEG方案具有较好的肠道清洁效果,较低的不良反应发生率,同时又可提升患者满意度及耐受性。Objective To explore the effect of linalotide combined with polyethylene glycol electrolytes powder(PEG)on intestinal preparation before colonoscopy in patients with constipation.Methods A total of 175 patients who underwent colonoscopy in the hospital from January to December 2022 were selected,including 58 cases in the control group,59 cases in the study group A,and 58 cases in the study group B.The Boston bowel preparation scale(BBPS)scores,incidence of adverse reactions,willingness to repeat,satisfaction with bowel preparation,and disease detection rate were compared among the three groups.Results There was no statistically significant difference in the total score of BBPS among the three groups(P>0.05).There was no statistically significant difference in BBPS score of left colon between the study group B and the control group(P>0.05),but compared with study group A,the difference was statistically significant(P<0.05).There was no statistically significant difference in the detection rate of lesions among the three groups(P>0.05).The incidence of adverse reactions(excluding abdominal pain and fatigue)in the control group was higher than that in the study group A and the study group B,with statistically significant difference(P<0.05).However,there was no statistically significant difference between the study group A and the study group B(P>0.05).The satisfaction with bowel preparation and willingness to repeat in the study group A and the study group B were higher than those in the control group,with statistically significant differences(P<0.05).However,there was no statistically significant difference between the study group A and the study group B(P>0.05).Conclusion For constipation groups with difficulty in intestinal preparation,the combination of linalotide and PEG regimen has good intestinal cleaning effects,low incidence of adverse reactions,and can improve patient satisfaction and tolerance.

关 键 词：利那洛肽 便秘 肠道准备 结肠镜检查 

分 类 号：R57[医药卫生—消化系统]