不同时机应用人免疫球蛋白治疗新生儿ABO溶血病的临床比较  

Clinical Comparison of Human Immunoglobulin in Treatment of Neonatal Abo Hemolytic Disease at Different Times

作　　者：顾志本 钟玉 GU Zhiben;ZHONG Yu(Department of Neonatology,Nanjing Gaochun People´s Hospital,Nanjing,Jiangsu Province,211300 China)

机构地区：[1]南京市高淳人民医院新生儿科,江苏南京211300

出　　处：《中外医疗》2023年第22期18-21,共4页China & Foreign Medical Treatment

摘　　要：目的探究对新生儿ABO溶血病患儿在不同时机应用人免疫球蛋白的效果。方法便利选取2018年2月—2021年11月期间南京市高淳人民医院医治的新生儿ABO溶血病患儿133例为研究对象,以随机数表法分为对照组(n=66)和观察组(n=67)。对照组在出生24~48 h内给予人免疫球蛋白治疗,观察组在出生后24 h内给予人免疫球蛋白治疗。比较两组临床效果、血常规指标、临床相关指标及并发症发生情况。结果观察组总有效率(98.51%)明显高于对照组(87.88%),差异有统计学意义(χ^(2)=4.387,P<0.05)。治疗后,观察组血清胆红素、网织红细胞计数低于对照组,观察组红细胞计数、血红蛋白、免疫球蛋白G、免疫球蛋白M及免疫球蛋白A高于对照组,差异有统计学意义(P<0.05)。观察组黄疸消失时间、住院时间、治疗时间均短于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率明显低于对照组,差异有统计学意义(P<0.05)。结论治疗新生儿ABO溶血病患儿时,在出生后24 h内给予人免疫球蛋白治疗,效果较为显著,能够改善血常规指标,缩短黄疸消失时间、住院时间、治疗时间,并降低并发症发生率。Objective To explore the effect of applying human immunoglobulin at different time in the treatment of neonatal ABO hemolytic disease.Methods 133 neonatal ABO hemolytic disease newborns treated at Nanjing Gaochun People´s Hospital from February 2018 to November 2021 were conveniently selected as the study subjects,and they were divided into control group(n=66)and observation group(n=67)using a random number table method.The control group received human immunoglobulin therapy within 24-48 hours of birth,while the observation group received human immunoglobulin therapy within 24 hours after birth.Compared the clinical efficacy,blood routine indicators,clinical related indicators,and incidence of complications between the two groups.Results The total effective rate of the observation group(98.51%)was significantly higher than that of the control group(87.88%),the difference was statistically significant(χ^(2)=4.387,P<0.05).After treatment,the serum bilirubin and reticulocyte count in the observation group were lower than those in the control group,while the red blood cell count,hemoglobin,immunoglobulin G,immunoglobulin M,and immunoglobulin A in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05).The disappearance time,hospitalization time,and treatment time of jaundice in the observation group were shorter than those in the control group,the difference was statistically significant(P<0.05).The incidence of complications in the observation group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion In the treatment of newborn ABO hemolytic patients,human immunoglobulin treatment within 24 h after birth has a significant effect,which can improve blood routine indicators,shorten the time of jaundice disappearance,hospital stay,treatment time,and reduce the incidence of complications.

关 键 词：不同时机 人免疫球蛋白 新生儿 ABO溶血病 临床效果 

分 类 号：R743[医药卫生—神经病学与精神病学]