Developing hierarchical microneedles for biomedical applications  

作　　者：Minhui Lu Xiaoxuan Zhang Zhiqiang Luo Yuanjin Zhao 

机构地区：[1]Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,School of Biological Science and Medical Engineering,Southeast University,Nanjing,210096,China [2]Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,Zhejiang 325001,China

出　　处：《Engineered Regeneration》2023年第3期316-327,共12页再生工程（英文）

基　　金：supported by the National Key Research and De-velopment Program of China (2022YFB4700100);the National Natu-ral Science Foundation of China (T2225003,52073060 and 61927805);the Nanjing Medical Science and Technique Development Foundation (ZKX21019);Guangdong Basic and Applied Basic Research Foundation (2021B1515120054);the Shenzhen Fundamental Research Pro-gram (JCYJ20190813152616459 and JCYJ20210324133214038).

摘　　要：As a new kind of microcarrier device,microneedles are featured by micrometer needle arrays with an overall size in the centimeter scale.Due to the needle shape and the micron size,microneedles can penetrate the skin without harming nerves and blood vessels,which causes many advantages such as minimally invasive,safe and convenient.The past few decades have witnessed a great leap in microneedles research.The main materials of microneedles have changed from metal and ceramic to polymers with more complex functions,and the optimiza-tion of materials and preparation strategies has led to a greater variety of microneedle styles.Among them,the construction or combination of smaller size structures or materials on microneedles to fabricate hierarchical mi-croneedles is a major research hotspot.Here,we present the recent research progress of hierarchical microneedles for biomedicine.We begin by discussing the fabrication strategies of hierarchical microneedles,including main-stream casting and coating methods based on microneedle molds and three dimensions(3D)printing methods.We then expand the discussion from the hierarchical microneedles with porous structure to those composited with nanomaterials.Eventually,we have a discussion about the research progress of hierarchical microneedles in the area of biomarkers detection and transdermal drug delivery,as well as its future development direction.

关 键 词：MICRONEEDLE Porous structure NANOMATERIALS Drug delivery DETECTION 

分 类 号：R318.08[医药卫生—生物医学工程]