尤瑞克林注射液对前循环急性脑梗死老年患者神经功能等的影响  

Effect of Urinary Kallidinogenase for injection on nerve functions and other related indexes in elderly patients with acute cerebral infarction of anterior circulation

作　　者：崔志军[1] 王秀芬 郭红玲[1] Cui Zhi-jun;Wang Xiu-fen;Guo Hong-ling(Department of Neurology,Huaxian People's Hospital,Huaxian 456400,Henan,China;Department of Neurology,The First People's Hospital of Xinxiang City,Xinxiang 453000,Henan,China)

机构地区：[1]滑县人民医院神经内科,河南滑县456400 [2]新乡市第一人民医院神经内科,河南新乡453000

出　　处：《四川生理科学杂志》2023年第10期1818-1821,共4页Sichuan Journal of Physiological Sciences

摘　　要：目的:分析老年前循环急性脑梗死患者在阿替普酶静脉溶栓基础上使用尤瑞克林的效果。方法:随机将2018年10月至2020年10月我科128例老年前循环急性脑梗死患者分组,64例常规组患者接受阿替普酶常规静脉溶栓治疗,64例联合组患者加用尤瑞克林注射液,对比临床疗效、脑血液流变学指标、神经相关因子水平、炎性因子水平、认知功能相关因子水平及不良反应。结果:治疗2 w后,联合组的总有效率、神经相关因子水平均高于常规组,脑血液流变学指标、炎性因子和认知功能相关因子水平均低于常规组(P<0.05);两组患者不良反应发生率差异无统计学意义。结论:老年前循环急性脑梗死患者采用阿替普酶常规静脉溶栓治疗基础上,加用尤瑞克林可有效改善患者相关认知功能、及神经功能相关血清因子和脑血液流变学指标水平,且安全性佳,值得推广。Objective:To analyze the effect of Urinary Kallidinogenase on the basis of intravenous thrombolysis with alteplase in elderly patients with anterior circulation acute cerebral infarction.Methods:A total of 128 elderly patients with precirculation acute cerebral infarction in our department from October 2018 to October 2020 were randomly divided into two groups.64 patients in the conventional group were received routine intravenous thrombolysis therapy with alteplase,and 64 patients in the combined group were added with Urinary Kallidinogenase for injection.The clinical efficacy,cerebral hemorheology indexes,neuro-related factors levels,inflammatory factors levels,cognitive function related factors levels and adverse reactions were compared.Results:After 2 w treatment,the total effective rate,the levels of neuro-related factors in combination group were higher than those in conventional group.The cerebral hemorheology indexes,levels of inflammatory factors and cognitive function related factors were lower than those of conventional group(P<0.05).There was no statistical significance in the incidence of adverse reactions between two groups.Conclusion:On the basis of conventional intravenous thrombolytic therapy with alteplase in elderly patients with acute cerebral infarction in the anterior circulation,the additional treatment of Urinary Kallidinogenase can effectively improve the relevant cognitive function,levels of neurological function-related serum factors and cerebral hemorheological index with good security;which is worthy of promotion.

关 键 词：前循环急性脑梗死 尤瑞克林 老年 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]