Enantioselective[3 t 2]cycloadditions of terminal allenoates withβ-sulfonyl-α,β-unsaturated ketones  

作　　者：Xiuzheng Li Jun Liao Xiaobin Zhuo Huamin Wang Xiaoyun Chai Yan Zou Qingjie Zhao 

机构地区：[1]Department of Organic Chemistry,School of Pharmacy,Second Military Medical University,Shanghai 200433,China [2]Zhangjiagang Hospital Affiliated to Soochow University,Zhang Jiagang 215600,China [3]Department of Biochemistry and Molecular Biology,College of Basic Medical Sciences,Second Military Medical University,Shanghai 200433,China [4]Shanghai Key Laboratory of Green Chemistry and Chemical Processes,Department of Chemistry,East China Normal University,Shanghai 200062,China

出　　处：《Green Synthesis and Catalysis》2023年第1期54-57,共4页绿色合成与催化（英文）

基　　金：The authors are grateful to NSFC(Nos.21971066 and 21772042)for financial support.Special thanks to prof;Junliang Zhang(Fudan University)for his kind suggestion on this[3 t 2]cycloaddition reaction.

摘　　要：A highly efficient and mild method for[3 t 2]cycloaddition ofβ-sulfonyl-α,β-unsaturated ketones with terminal allenoates was well-explored and developed.The reactions were successfully performed by applying multifunctional chiral phosphine P6 which was screened from eight chiral phosphorus reagents to finally result in a variety of enantioenriched sulfone-substituted cyclopentenes with two chiral centers(up to 81%yield with 94%ee).Moreover,2.5 mol%catalytic equivalents were proved to be feasible when this reaction was performed on a 10 mmol scale.

关 键 词：[3t2]Cycloadditions Terminal allenoates α β-Unsaturated ketones ENANTIOSELECTIVE Chiral phosphine 

分 类 号：O62[理学—有机化学]