Dietary fiber during gestation improves lactational feed intake of sows by modulating gut microbiota  

作　　者：Shuang Li Jie Zheng Jiaqi He Hao Liu Yingyan Huang Liansu Huang Ke Wang Xilun Zhao Bin Feng Lianqiang Che Zhengfeng Fang Jian Li Shengyu Xu Yan Lin Xuemei Jiang Lun Hua Yong Zhuo De Wu 

机构地区：[1]Key Laboratory for Animal Disease‑Resistance Nutrition of China Ministry of Education,Institute of Animal Nutrition,Sichuan Agricultural University,No.211,Huimin Road,Wenjiang District,Chengdu 611130,Sichuan,People’s Republic of China

出　　处：《Journal of Animal Science and Biotechnology》2023年第5期2012-2032,共21页畜牧与生物技术杂志（英文版）

基　　金：supported by National Science Foundation of Sichuan Province[2023NSFSC0010];National Natural Science Foundation of China[32230102];the Major Scientific and Technological Special Project of Sichuan Province[No.2021ZDZX0009];National Modern Agricultural Industry Technology System Sichuan Pig innovation team[scsztd-2023-08-03].

摘　　要：Background The feed intake of sows during lactation is often lower than their needs.High-fiber feed is usually used during gestation to increase the voluntary feed intake of sows during lactation.However,the mechanism underlying the effect of bulky diets on the appetites of sows during lactation have not been fully clarified.The current study was conducted to determine whether a high-fiber diet during gestation improves lactational feed intake(LFI)of sows by modulating gut microbiota.Methods We selected an appropriate high-fiber diet during gestation and utilized the fecal microbial transplanta-tion(FMT)method to conduct research on the role of the gut microbiota in feed intake regulation of sows during lactation,as follows:high-fiber(HF)diet during gestation(n=23),low-fiber(LF)diet during gestation(n=23),and low-fiber diet+HF-FMT(LFM)during gestation(n=23).Results Compared with the LF,sows in the HF and LFM groups had a higher LFI,while the sows also had higher peptide tyrosine tyrosine and glucagon-like peptide 1 on d 110 of gestation(G110 d).The litter weight gain of piglets during lactation and weaning weight of piglets from LFM group were higher than LF group.Sows given a HF diet had lower Proteobacteria,especially Escherichia-Shigella,on G110 d and higher Lactobacillus,especially Lactobacil-lus_mucosae_LM1 and Lactobacillus_amylovorus,on d 7 of lactation(L7 d).The abundance of Escherichia-Shigella was reduced by HF-FMT in numerically compared with the LF.In addition,HF and HF-FMT both decreased the perinatal concentrations of proinflammatory factors,such as endotoxin(ET),lipocalin-2(LCN-2),tumor necrosis factor-α(TNF-α),and interleukin-1β(IL-1β).The concentration of ET and LCN-2 and the abundance of Proteobacteria and Escheri-chia-Shigella were negatively correlated with the LFI of sows.Conclusion The high abundance of Proteobacteria,especially Escherichia-Shigella of LF sows in late gestation,led to increased endotoxin levels,which result in inflammatory responses and adverse effects on the LFI of sows

关 键 词：Dietary fiber Escherichia-Shigella Feed intake LACTOBACILLUS SOW 

分 类 号：S828[农业科学—畜牧学]