MTA1、PTEN、PD⁃L1检测在老年肺癌患者术前分期及淋巴结转移中的临床价值  

Clinical value of MTA1,PTEN and PD⁃L1 detection in preoperative staging and lymph node metastasis in elderly patients with lung cancer

作　　者：赵曦雯 张玉梅[1] 刘慧 ZHAO Xiwen;ZHANG Yumei;LIU Hui(Department of Geriatrics,Sanya Central Hospital(Hainan Third People's Hospital),Sanya,Hainan,China,572000)

机构地区：[1]三亚中心医院(海南省第三人民医院)老年医学科,海南三亚572000

出　　处：《分子诊断与治疗杂志》2023年第9期1622-1626,共5页Journal of Molecular Diagnostics and Therapy

基　　金：海南省医学科研基金资助项目(20A61820311)。

摘　　要：目的探究肿瘤转移相关基因1(MTA1)、磷酸酯酶与张力蛋白同源物(PTEN)、程序性细胞死亡配体1(PD⁃L1)检测在老年肺癌患者术前分期及淋巴结转移中的临床价值。方法选取2020年1月至2023年1月于三亚中心医院就诊的老年肺癌患者217例作为观察组,纳入同期体检健康老年人62名作为对照组,比较两组血清MTA1、PTEN、PD⁃L1表达水平,并比较不同术前分期及不同淋巴结转移状态的老年肺癌患者MTA1、PTEN、PD⁃L1水平差异,评估其在肺癌患者淋巴结转移中的临床价值。结果与对照组比较,观察组血清MTA1、PD⁃L1表达水平均升高,PTEN表达水平降低,差异有统计学意义(P<0.05);217例老年肺癌患者中,Ⅰ期34例,Ⅱ期67例,Ⅲa期116例,不同术前分期老年肺癌患者肿瘤大小、肿瘤分化程度、淋巴结转移情况比较差异有统计学意义(P<0.05);MTA1、PD⁃L1表达水平随术前分期升高而升高(P<0.05),PTEN表达水平随随术前分期升高而降低(P<0.05);217例老年肺癌患者中淋巴转移患者114例,与非淋巴转移组比较,淋巴结转移组患者MTA1、PD⁃L1表达水平升高,PTEN表达水平降低,差异均有统计学意义(P<0.05);ROC曲线结果显示,MTA1、PTEN、PD⁃L1单一及三者联合诊断的AUC分别为0.972、0.737、0.806和0.934,其中三者联合诊断的敏感度、特异度最高,分别为0.904和0.884(P<0.05)。结论不同术前分期和不同淋巴结转移状态的老年肺癌患者MTA1、PTEN、PD⁃L1表达水平存在显著差异,三指标联合诊断对肺癌淋巴结转移的评估具有参考价值。Objective To explore the evaluated value of detection of metastasis⁃associated protein 1(MTA1),phosphatase and tensin homolog(PTEN),programmed cell death protein ligand 1(PD⁃L1)in the preoperative staging and lymph node metastasis in elderly patients with lung cancer.Methods 217 elderly patients with lung cancer who came to the hospital from January 2020 to January 2023 were selected as the ob⁃servation group,and 62 healthy elderly people who underwent physical examination during the same period were included.Serum MTA1,PTEN and PD⁃L1 were compared between the two groups,and the differences in MTA1,PTEN and PD⁃L1 were compared among elderly patients with different preoperative stages and lymph node metastasis status,and analyzed their clinical value on lymph node metastasis in elderly patients with lung cancer.Results Compared with the control group,the expression levels of serum MTA1 and PD⁃L1 were increased while the expression levels of serum PTEN were decreased in the observation group(P<0.05).Among 217 elderly patients with lung cancer,there were 34 cases in stageⅠ,67 cases in stageⅡand 116 cases in stageⅢA.There were statistically significant differences in tumor size,tumor differentiation degree and lymph node metastasis among elderly patients with different preoperative stages(P<0.05).The expression levels of MTA1 and PTEN were increased with the increase of preoperative staging(P<0.05)while the expression lev⁃el of PTEN was decreased with the increase of preoperative staging(P<0.05).Among 217 elderly patients with lung cancer,there were 114 cases with lymph node metastasis.Compared with the non⁃lymph node metastasis group,the expression levels of MTA1 and PD⁃L1 in the lymph node metastasis group were enhanced(P<0.05)while the expression level of PTEN was reduced(P<0.05).The ROC curve results showed that the AUCs of MTA1,PTEN and PD⁃L1 alone and in combination were 0.972,0.737,0.806 and 0.934 respectively,and the sensitivity and specificity of the combined diagnosis were the high

关 键 词：肺癌 肿瘤转移相关基因1 磷酸酯酶与张力蛋白同源物 程序性细胞死亡配体1 术前分期 淋巴结转移 

分 类 号：R734.2[医药卫生—肿瘤] R730.43[医药卫生—临床医学]