丁苯酞联合左乙拉西坦治疗脑卒中后继发性癫痫的效果  

Effect of butylphthalide combined with levetiracetam on the treatment of secondary epilepsy after stroke

作　　者：王少津 陈海荣[1] 潘碧云 WANG Shaojin;CHEN Hairong;PAN Biyun(General Department of Haikou People's Hospital,Haikou,Hainan,China,570000)

机构地区：[1]海口市人民医院全科,海南海口570000

出　　处：《分子诊断与治疗杂志》2023年第9期1646-1649,共4页Journal of Molecular Diagnostics and Therapy

基　　金：海南省卫生健康行业科研项目(21A200426)。

摘　　要：目的研究丁苯酞联合左乙拉西坦治疗脑卒中后继发性癫痫的疗效,并探讨其对炎性反应、氧化应激指标(GSH⁃Px,SOD)、神经营养因子(BDNF、NGF)水平的影响。方法选取2021年10月至2022年10月在海口市人民医院综合科收治的66例脑卒中后继发性癫痫患者作为研究对象,按照随机数字表法,将其分成两组,对照组的33例患者给予左乙拉西坦治疗,研究组的33例患者给予丁苯酞联合左乙拉西坦治疗,观察两组的疗效以及炎性因子、氧化应激指标及神经营养因子水平的变化。结果研究组的临床总有效率明显高于对照组,差异有统计学意义(χ^(2)=3.995,P<0.05);治疗前,两组患者的炎性因子肿瘤坏死因子、白介素⁃2的水平,差异无统计学意义(t=0.377、0.627,P>0.05);治疗后,研究组患者的肿瘤坏死因子、白介素⁃2水平低于对照组,差异有统计学意义(t=7.381、6.675,P<0.05);治疗前,两组患者的氧化应激指标及神经营养因子的水平差异无统计学意义(t=0.081、0.156、0.089、0.622,P>0.05);治疗后,氧化应激指标神经营养因子的水平均明显高于对照组,差异有统计学意义(t=9.331、20.745、5.453、3.599,P<0.05)。结论丁苯酞联合左乙拉西坦可有效治疗脑卒中后继发性癫痫,降低患者炎性反应,值得在临床上推广应用。Objective To study the effect of butylphthalide combined with levetiracetam on the treatment of secondary epilepsy after stroke,and to explore its influences on inflammatory response,oxidative stress index(GSH⁃Px,SOD)and neurotrophic factor(BDNF,NGF)level.Methods A total of 66 patients with secondary epilepsy after stroke admitted to the General Department of Haikou People's Hospital from October 2021 to October 2022 were selected as the study objects,and they were divided into two groups according to the random number table method,33 patients in the control group were treated with levetiracetam,and 33 patients in the study group were treated with butylphthalide and levetiracetam,the therapeutic effect,inflammatory factors,oxidative stress and neurotrophic factors were compared.Results The total clinical effective rate in the study group was significantly higher than that in the control group(χ^(2)=3.995,P<0.05).Before treatment,there was no significant difference in the levels of tumor necrosis factor and IL⁃2 between the two groups(t=0.377,0.627,P>0.05).After treatment,the levels of tumor necrosis factor and interleukin⁃2 in the study group were significantly lower than those in the control group(t=7.381,6.675,P<0.05).Before treatment,the levels of oxidative stress indicators glutathione peroxidase,superoxide dismutase,neurotrophin,brain⁃derived neurotrophic factor and nerve growth factor in the two groups had no significant difference(t=0.081,0.156,0.089,0.622,P>0.05).After treatment,the levels of glutathione peroxidase,superoxide dismutase,brain⁃derived neurotrophic factor and nerve growth factor in the study group were significantly higher than those in the control group(t=9.331,20.745,5.453,3.599,P<0.05).Conclusions Butylphthalide combined with levetiracetam can effectively treat secondary epilepsy after stroke and reduce the inflammatory response of patients,which is worthy of clinical application.

关 键 词：丁苯酞 左乙拉西坦 脑卒中后继发性癫痫 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R742.1[医药卫生—临床医学]