内源性阿片类系统与非自杀性自伤关系的研究进展  

The research progress in endogenous opioid system and non-suicidal self-injury

作　　者：干欣翊 刘晓华 GAN Xin-yi;LIU Xiao-hua(Shanghai Mental Health Center,Shanghai Jiaotong University School of Medicine,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心,200030

出　　处：《临床精神医学杂志》2023年第5期412-414,共3页Journal of Clinical Psychiatry

基　　金：上海市公共卫生体系建设三年行动计划(2020-2022年)(GWV-10.2-XD28)。

摘　　要：近年来非自杀性自伤(Non-suicidal self-injury,NSSI)受到越来越多的关注。NSSI常见于青少年,常反复发生,危害严重,是自杀的重要预测因子。研究发现内源性阿片类系统异常与NSSI有关,可能是NSSI发生的重要神经机制之一,为探索针对性的治疗手段提供了潜在的生物靶点。本文对NSSI与自杀的关系、内源性阿片类系统在NSSI的作用,基于内源性阿片类系统对NSSI进行干预等方面的研究进展进行综述,希望为NSSI早识别、早干预,进而预防NSSI和自杀提供理论依据。Non-suicidal self-injury(NSSI)has received more and more attention in recent years.NSSI is common,occurring repeatedly,and often causing great damage in adolescents.It is an important predictor of suicide.Evidence suggested that the abnormality of the endogenous opioid system was related to NSSI,which may be one of the crucial neural mechanisms of NSSI,providing a possible biological target for exploring treatment for NSSI.This article reviews the research progress of the relationship between NSSI and suicide,the role of the endogenous opioid system in the NSSI,and the intervention for NSSI based on the endogenous opioid system,hoping to provide a direction for early identification and early intervention for NSSI,and then prevent recurrent NSSI and suicide.

关 键 词：内源性阿片类物质 阿片受体 非自杀性自伤 自杀 抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]