1,1-Regioselective alkenylboration of styrenes enabled by palladium catalysis  

作　　者：Dong Wu Hailiang Pang Guoyin Yin 

机构地区：[1]The Institute for Advanced Studies,Wuhan University,Wuhan 430072,China

出　　处：《Chinese Chemical Letters》2023年第8期175-179,共5页中国化学快报（英文版）

基　　金：This work was supported by grants from the National Natural Science Foundation of China(No.22122107);the Fundamental Research Funds for Central Universities(No.2042021kf0190).

摘　　要：Despite the 1,2-difunctionalization reactions of styrenes have been well developed, the 1,1-regioselective addition reaction remains challenging. We disclose herein a palladium-catalyzed, highly 1,1-regioselective alkenylboration of styrenes by using alkenyl triflates and a diboron reagent as the coupling partners. A wide scope of styrenes derivatives and alkenyl triflates participate this reaction to provide the corresponding allyl boronates with high regioisomeric ratios. The success of this reaction is ascribed to the application of 1,10-phenanthroline-derivated ligand and the addition of ammonium chloride salt. Moreover, acrylate esters can also selectively afford the 1,1-alkenylboration products under the same reaction conditions.

关 键 词：STYRENES 1 1-Regioselectivity Chain-walking Palladium catalysis Allyl boronates 

分 类 号：TQ426[化学工程] TQ241.21