Build in seconds:Small-molecule hydrogels of self-assembled tryptophan derivatives  

作　　者：Xianwen Song Jun Zheng Shunmei He Yilin Liu Shutong Yang Qiang Li Chuntai Liu Zequn Zhang Xi Liu Chunyan Deng Yi Zhang 

机构地区：[1]Hunan Provincial Key Laboratory of Micro&Nano Materials Interface Science,College of Chemistry and Chemical Engineering,Central South University,Changsha 410083,China [2]Beijing National Laboratory for Molecular Sciences(BNLMS),CAS Key Lab of Colloid,Interface and Chemical Thermodynamics Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China [3]Key Laboratory of Materials Processing and Mold(Zhengzhou University),Ministry of Education,Zhengzhou 450002,China [4]Department of Gastrointestinal Surgery,The Third Xiangya Hospital of Central South University,Changsha 410013,China

出　　处：《Chinese Chemical Letters》2023年第8期219-222,共4页中国化学快报（英文版）

基　　金：This work was financially supported by the National Natural Science Foundation of China(Nos.21773311 and 21972169);Hunan Provincial Science and Technology Plan Project(No.2017TP1001);Thanks for the software support provided by the High Performance Computing Center of CSU and NMR data support provided by the Institute of Chemistry Chinese Academy of Sciences.

摘　　要：Small-molecule hydrogels based on amino acid derivatives have promising applications in many biological fields,including cell culture,drug delivery,and tissue engineering.Although these hydrogels have been widely reported to have low cytotoxicity,biocompatibility,and tunable bioactivity,problems such as harsh preparation conditions and complex material design hinder their application.Herein,by adjusting pH to induce non-covalent interactions between small-molecule tryptophan derivatives(N-[(phenylmethoxy)carbonyl]-L-tryptophan,Mw:338.35),we developed a self-assembled three-dimensional network hydrogel that can be rapidly formed in seconds.And the supramolecular self-assembly mechanism of the hydrogels was also investigated in detail through experimental characterizations and density functional theory calculation.As-prepared hydrogels also exhibit reversible pH-stimulated response and self-healing properties.This study details a research process for the simple and rapid preparation of tryptophan derivative-based hydrogels,which provides more reference ideas for the future development of materials based on other amino acid derivatives.

关 键 词：SMALL-MOLECULE Hydrogel Tryptophan derivatives SELF-ASSEMBLE SELF-HEALING Density functional theory 

分 类 号：TQ427.26[化学工程] R318.08[医药卫生—生物医学工程]