基于3D打印导板引导下125⁃I放射性粒子植入治疗头颈部恶性肿瘤的疗效评价  

Efficacy evaluation of 125⁃I radioactive seed implantation in the treatment of head and neck malignant tumors based on pre⁃planned 3D printing guide plate

作　　者：克热木·阿巴司[1,2] 郭治辰 龚忠诚 Keremu Abasi;GUO Zhi-chen;GONG Zhong-cheng(The First Affiliated Hospital of Xinjiang Medical University/Affiliated Stomatological Hospital,Maxillofacial Surgery,Xinjiang Uygur Au-tonomous Region Institute of Stomatology,Xinjiang Urumqi 830054,China;Xinjiang Uygur Autonomous Region Institute of Stomatology,Xinjiang Urumqi 830054,China;Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Re-search,College of Stomatology,Xi’an Jiaotong University,Shaanxi Xi’an 710004,China;Laboratory Center of Stomatology,College of Stomatology,Xi’an Jiaotong University,Shaanxi Xi’an 710004,China;Department of Oral and Maxillofacial Surgery,College of Stomatology,Xi’an Jiaotong University,Shaanxi Xi’an 710004,China)

机构地区：[1]新疆医科大学第一附属医院(附属口腔医院)颌面肿瘤外科,新疆乌鲁木齐830054 [2]新疆维吾尔自治区口腔医学研究所新,疆乌鲁木齐830054 [3]西安交通大学口腔医院陕西省颅颌面精准医学研究重点实验室,陕西西安710004 [4]陕西省牙颌疾病临床研究中心,陕西西安710004 [5]西安交通大学口腔医院口腔颌面外科,陕西西安710004

出　　处：《临床口腔医学杂志》2023年第9期532-536,共5页Journal of Clinical Stomatology

基　　金：新疆维吾尔自治区自然科学基金面上项目(编号:2021D01C321);陕西省卫生健康委员会科研基金项目,D类扶植项目(编号:2022D033)。

摘　　要：目的:探讨基于3D打印导板引导下125⁃I放射性粒子植入治疗头颈部恶性肿瘤的优势。方法:收集新疆医科大学附属口腔医院颌面肿瘤外科2016年1月~2022年1月收治入院并诊断为头颈部恶性肿瘤患者共40例,数字化设计联合3D打印组(n=20)和传统组(n=20),对比两种手术方法的手术效果,评价术后疼痛、肿瘤直径变化、肿瘤转移及复发等情况。结果:实施3D打印导板引导下进行粒子植入的患者,其手术时间较传统手术组明显缩短,术后疼痛明显减轻。采用3D打印导板引导下进行粒子植入患者的肿瘤最大直径较传统手术组明显缩小。结论:数字化设计联合3D打印技术辅助125⁃I粒子植入术不仅提高了手术的精确性,而且减少手术时间和患者术后的疼痛,值得临床推广。Objective:To evaluate the advantages of 125⁃I radioactive seed implantation in the treatment of head and neck malignant tumors based on a preplanned 3D printed guide plate.Methods:A total of 40 patients diagnosed with head and neck malignant tumor admitted to the Department of Maxillofacial Tumor Surgery,Affiliated Stomatological Hospital of Xinjiang Medical University from January 2016 to January 2022 were collected,including the digital design combined with 3D printing group(n=20)and the traditional group(n=20).The operative effect and postoperative pain of the two methods were compared.Results:Compared with the traditional operation group,the operation time and postoperative pain of the patients with 3D printing for seed implantation were significantly shorter.The maximum tumor diameter in patients guided by 3D print⁃ing was significantly smaller than that in the traditional group.Conclusion:Digital design combined with 3D printing technolo⁃gy to assist 125⁃I seed implantation not only improves the accuracy of the operation,but also reduces the operation time and postoperative pain of patients,which is worthy of clinical promotion.

关 键 词：头颈部恶性肿瘤 3D打印 125⁃I 放疗 数字化设计 

分 类 号：R739.8[医药卫生—肿瘤]