Low back pain and osteoarthritis pain:a perspective of estrogen  

作　　者：Huiwen Pang Shihui Chen David M.Klyne David Harrich Wenyuan Ding Sidong Yang Felicity Y.Han 

机构地区：[1]Australian Institute for Bioengineering and Nanotechnology,The University of Queensland,St.Lucia,Brisbane,QLD 4072,Australia [2]NHMRC Centre of Clinical Research Excellence in Spinal Pain,Injury and Health,The University of Queensland,St.Lucia,Brisbane,QLD 4072,Australia [3]Department of Cell and Molecular Biology,QIMR Berghofer Medical Research Institute,Herston,QLD 4006,Australia [4]Department of Spine Surgery,The Third Hospital of Hebei Medical University,139 Ziqiang Road,Shijiazhuang 050051,China [5]Hebei Joint International Research Center for Spinal Diseases,139 Ziqiang Road,Shijiazhuang 050051,China

出　　处：《Bone Research》2023年第3期443-456,共14页骨研究（英文版）

基　　金：supported by the Natural Science Foundation of China (No.81871800 and 82072496)granted to W.D.;the Natural Science Foundation of Hebei Province (No.H2020206203)granted to S.Y.;a National Health and Medical Research Council (NHMRC)Australia Ideas Grant (No.2011398) granted to D.H.;supported by the Assistant Secretary of Defense for Health Affairs endorsed by the US Department of Defense through the FY19 Chronic Pain Management Research Program (D.M.K:award no.W81XWH2010909)。

摘　　要：Low back pain(LBP)is the world's leading cause of disability and is increasing in prevalence more rapidly than any other pain condition.Intervertebral disc(IVD)degeneration and facet joint osteoarthritis(FJOA)are two common causes of LBP,and both occur more frequently in elderly women than in other populations.Moreover,osteoarthritis(OA)and OA pain,regardless of the joint,are experienced by up to twice as many women as men,and this difference is amplified during menopause.Changes in estrogen may be an important contributor to these pain states.Receptors for estrogen have been found within IVD tissue and nearby joints,highlighting the potential roles of estrogen within and surrounding the IVDs and joints.In addition,estrogen supplementation has been shown to be effective at ameliorating IVD degeneration and OA progression,indicating its potential use as a therapeutic agent for people with LBP and OA pain.This review comprehensively examines the relationship between estrogen and these pain conditions by summarizing recent preclinical and clinical findings.The potential molecular mechanisms by which estrogen may relieve LBP associated with IVD degeneration and FJOA and OA pain are discussed.

关 键 词：AGENT DEGENERATION PAIN 

分 类 号：R684.3[医药卫生—骨科学]