MSS型结直肠癌肿瘤微环境及免疫联合治疗研究进展  

Research progress on tumor microenvironment and immune combination therapy of MSS colorectal cancer

作　　者：徐良富 李袁飞[2] Xu Liangfu;Li Yuanfei(First Clinical College of Shanxi Medical University,Taiyuan 030001,China;Department of Oncology,First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一临床医学院,太原030001 [2]山西医科大学第一医院肿瘤科,太原030001

出　　处：《国际肿瘤学杂志》2023年第3期186-190,共5页Journal of International Oncology

摘　　要：近年来,免疫治疗尤其是免疫检查点抑制剂在延长肿瘤晚期患者生存期方面显现出明显优势,肿瘤微环境是影响免疫疗效的重要因素之一。微卫星稳定型结直肠癌患者在联合免疫检查点抑制剂治疗中表现出免疫应答。深入探索微卫星稳定型结直肠癌的肿瘤微环境特点以及应用免疫检查点抑制剂联合治疗策略,可为结直肠癌免疫治疗提供新的思路和方向。In recent years,immunotherapy,especially immune checkpoint inhibitors,has shown obvious advantages in prolonging the survival of patients with advanced tumors,and the tumor microenvironment is one of the important factors affecting the efficacy of immunity.Patients with microsatellitestable colorectal cancer exhibit immune responses in combination with immune checkpoint inhibitor therapy.In-depth exploration of the tumor microenvironment characteristics of microsatellite-stable colorectal cancer and the application of combined immune checkpoint inhibitor therapy can provide new ideas and directions for colorectal cancer immunotherapy.

关 键 词：结直肠肿瘤 肿瘤微环境 免疫疗法 微卫星稳定型 

分 类 号：R735.34[医药卫生—肿瘤]