基底浆细胞增多预测溃疡性结肠炎复发风险的Meta分析  

Clinical value of basal plasmacytosis in predicting the recurrence risk of ulcerative colitis:a meta analysis

作　　者：崔家玮 李秀娟 高鸿亮[1] 张志强[1] CUI Jia-wei;LI Xiu-juan;GAO Hong-liang;ZHANG Zhi-qiang(Second Department of Gastroenterology,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,Xingjiang,CHINA;Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Xinjiang Medical University,Urumqi 830011,Xingjiang,CHINA)

机构地区：[1]新疆医科大学第一附属医院消化病二科,新疆乌鲁木齐830011 [2]新疆医科大学基础医学院病理生理学教研室,新疆乌鲁木齐830011

出　　处：《海南医学》2023年第17期2553-2558,共6页Hainan Medical Journal

基　　金：新疆维吾尔自治区自然科学基金杰出青年项目(编号:2022D01E25)。

摘　　要：目的系统评价基底浆细胞增多(BPC)预测溃疡性结肠炎(UC)复发风险的临床应用价值。方法通过检索中国生物医学文献数据库、中国学术期刊网络出版总库、PudMed和EMbase等国内外权威数据库,全面收集相关的临床研究,按纳入排除标准筛选文献并收集相关数据和信息,采用STATA 16.0统计软件进行Meta分析,并对人数、研究类型、随访时间、内镜下缓解标准等进行亚组分析。结果纳入10项研究,共计837例患者。BPC与复发风险的总体增加相关(OR=2.213,95%CI:1.323~3.700);亚组分析结果显示,研究人数≥70人(OR 2.719,95%CI:1.796~4.119)、随访时间长(>12个月)(OR 2.408,95%CI:1.427~4.063)、内镜下缓解标准MES≤1(OR 2.881,95%CI:1.842~4.506)均与较高的复发率有关。结论在内镜缓解的UC患者中,BPC与较高的复发率相关,在临床中可将BPC作为预测UC复发的组织学特征。Objective To evaluate the clinical value of basal plasmacytosis(BPC)in predicting the recurrence risk of ulcerative colitis(UC).Methods Relevant clinical studies were collected comprehensively from Chinese Biomedical Literature Database(CBM),Chinese National Knowledge Infrastructure(CNKI),PudMed,EMbase,and other databases,and the relevant data and information were selected according to the inclusion and exclusion criteria.Meta analysis was carried out by STATA 16.0,and subgroup analyses were conducted through the number,research type,follow-up time,endoscopic remission criteria.Results A total of 837 patients were included in 10 the studies selected.BPC was associated with the overall increased risk of recurrence(OR=2.213,95%CI 1.323-3.700).Subgroup analysis showed that the number of people≥70(OR 2.719,95%CI 1.796-4.119),long follow-up(>12 months)(OR 2.408,95%CI 1.427-4.063),and endoscopic remission criteria MES≤1(OR 2.881,95%CI 1.842-4.506)were all associated with a higher risk of recurrence.Conclusion In UC patients with endoscopic remission,BPC is associated with a higher recurrence rate,and BPC can be used as a histological feature to predict the recurrence of UC in clinic.

关 键 词：溃疡性结肠炎 组织学 基底浆细胞增多 复发 META分析 

分 类 号：R574.62[医药卫生—消化系统]