血清白细胞介素23、血管内皮生长因子与宫颈癌患者临床预后的相关性  

Correlation between serum interleukin-23,vascular endothelial growth factor and clinical prognosis in patients with cervical cancer

作　　者：汪莹[1] 姚满红 刘玉凤[1] 艾志刚[1] WANG Ying;YAO Man-hong;LIU Yu-feng;AI Zhi-gang(Department of Gynecology Tangshan,Maternal and Child Health Care Hospital,Hebei Province,Tangshan 063000,China)

机构地区：[1]河北省唐山市妇幼保健院妇科,河北唐山063000

出　　处：《河北医科大学学报》2023年第9期1037-1042,共6页Journal of Hebei Medical University

基　　金：河北省医学科学研究课题计划(20221756)。

摘　　要：目的探讨血清白细胞介素(interleukin,IL)23、血管内皮生长因子(vascular endothelial growth factor,VEGF)与宫颈癌患者临床预后的相关性。方法选取医院收治的宫颈癌患者410例作为研究对象,调查患者基线资料,并检测血清IL-23、VEGF等相关指标;随访1年,以复发作为临床预后的判定标准,采用COX回归分析血清IL-23、VEGF水平与患者临床预后的相关性;绘制ROC曲线和决策曲线,分析血清IL-23、VEGF水平预测患者临床预后的价值。结果410例宫颈癌患者随访结束时,有62例复发,复发率为15.12%;预后不良组血清IL-23、VEGF、糖类抗原(carbohydrate antigen,CA)125、鳞状细胞癌抗原(squamous cell carcinoma antigen,SCC-Ag)水平均高于预后良好组,差异有统计学意义(P<0.05);2组年龄、体重指数、孕次、产次、国际妇产科联盟(International Federation of Gynecology and Obstetrics,FIGO)分期、病理类型、肿瘤直径、血红蛋白(hemoglobin,Hb)、白细胞计数(white blood cell,WBC)、红细胞计数(red blood cell count,RBC)及血小板(blood platelet,PLT)水平比较,差异无统计学意义(P>0.05);经COX回归分析显示,血清SCC-Ag、CA125、IL-23、VEGF水平与宫颈癌患者临床预后有关(P<0.05);绘制受试者工作特征曲线(receiver operating characteristi,ROC)显示,血清IL-23、VEGF水平单独及联合预测宫颈癌患者临床预后的曲线下面积(area under curve,AUC)均>0.7,均有一定预测价值,但以联合预测的价值最好;决策曲线分析结果显示,在0.10~0.45、0.49~0.59、0.61~0.77的阈值概率区间,血清IL-23、VEGF水平联合预测宫颈癌临床预后的净收益率优于单一血清IL-23、VEGF水平。结论血清IL-23、VEGF水平与宫颈癌患者临床预后相关。Objective To investigate the correlation between serum interleukin-23(IL-23),vascular endothelial growth factor(VEGF)and clinical prognosis in patients with cervical cancer.Methods A total of 410 patients with cervical cancer treated in the hospital were selected as the research subjects.The baseline data of patients were investigated,and serum IL-23,VEGF and other related indicators were detected.The patients were followed up for 1 year.Recurrence was taken as the criterion of clinical prognosis.The correlation between the levels of serum IL-23 and VEGF and the clinical prognosis was analyzed by COX regression,and the ROC curve and decision-making curve were drawn to analyze the value of serum IL-23 and VEGF levels in predicting the clinical prognosis of patients.Results At the end of the follow-up of 410 patients with cervical cancer,62 cases recurred,and the recurrence rate was 15.12%.The levels of serum IL-23,VEGF,carbohydrate antigen(CA)125 and squamous cell carcinoma antigen(SCC-Ag)in the poor prognosis group were higher than those in the good prognosis group,and the difference was statistically significant(P<0.05).There was no statistical significant difference between two groups in age,body mass index,pregnancy times,parity,International Federation of Gynecology and Obstetrics(FIGO)stage,pathological type,tumor diameter,hemoglobin(Hb),white blood cell count(WBC),red blood cell count(RBC)and platelet(PLT)levels(P>0.05).COX regression analysis showed that the levels of serum SCC Ag,CA125,IL-23 and VEGF were related to the clinical prognosis of cervical cancer patients(P<0.05).The receiver operating characteristic(ROC)curve revealed that the area under the ROC curve(AUC)of serum IL-23 and VEGF level alone and in combination in predicting the clinical prognosis of cervical cancer patients was>0.7,showing certain predictive value,but combined prediction was of the highest value.The results of decision curve analysis showed that in the threshold probability interval of 0.1-0.45,0.49-0.59 and 0.61-0.77,the net b

关 键 词：宫颈肿瘤 白细胞介素23 血管内皮生长因子A 

分 类 号：R737.33[医药卫生—肿瘤]