PRF膜覆盖Bio-oss植骨材料表面对前牙美学区牙种植软组织增量的影响及其美学效果  

The effect of PRF membrane covering the surface of Bio-oss bone graft material on the soft tissue augmentation of dental implants in aesthetic area of anterior teeth and its aesthetic effect

作　　者：段立立 薛毅 郭康 刘琪 卞玉新 李慧 DUAN Li-li;XUE Yi;GUO Kang;LIU Qi;BIAN Yu-xin;LI Hui(Department of Stomatology,the 980th Hospital of Joint Logistic Support Force of PLA,Hebei Province,Shijiazhuang 050000,China)

机构地区：[1]中国人民解放军联勤保障部队第九八〇医院口腔科,河北石家庄050000

出　　处：《河北医科大学学报》2023年第9期1063-1067,共5页Journal of Hebei Medical University

基　　金：河北重点科技研究计划(20191217)。

摘　　要：目的探究富血小板纤维蛋白(platelet-rich fibrin,PRF)膜覆盖Bio-oss植骨材料表面对前牙美学区牙种植软组织增量的影响及其美学效果。方法选取前牙美学区种植(单颗牙)患者80例,按照随机数字表法分为对照组和研究组,每组40例。对照组以Bio-gide生物膜覆盖Bio-oss植骨材料表面,研究组以PRF膜覆盖Bio-oss骨材料表面。比较2组种植区创面愈合时间、种植优良率、种植后软组织增量(附着龈宽度增量、附着龈厚度增量)、咬合力、咀嚼效率、龈沟液炎性因子[高敏C反应蛋白(highsensitivity C-reactive protein,hs-CRP)、基质金属蛋白酶2(matrix metalloproteinase-2,MMP-2)、白细胞介素6(interleukin-6,IL-6)]水平、前牙美学效果[红色美学指数(pink ethetic scot,PES)、白色美学评分(white ethetic score,WES)]。结果研究组种植区创面愈合时间短于对照组,种植优良率高于对照组(P<0.05)。种植后3个月和种植后6个月,研究组附着龈宽度增量、附着龈厚度增量大于对照组,差异有统计学意义(P<0.05);研究组种植后6个月附着龈宽度增量、附着龈厚度增量大于种植后3个月(P<0.05)。种植后6个月,2组咬合力、咀嚼效率均高于种植后即刻,研究组咬合力、咀嚼效率均高于对照组,差异有统计学意义(P<0.05)。种植后3周,2组龈沟液hs-CRP、MMP-2、IL-6水平低于种植后即刻,研究组龈沟液hs-CRP、MMP-2、IL-6水平低于对照组,差异有统计学意义(P<0.05)。种植后6个月,2组PES、WES分值高于种植后即刻,研究组PES、WES分值高于对照组,差异有统计学意义(P<0.05)。结论PRF膜覆盖Bio-oss植骨材料表面能有效改善前牙美学区牙种植软组织增量,且能有效促进种植区创面愈合,提高种植优良率,改善患者口腔功能及美学效果。Objective To investigate the effect of platelet-rich fibrin(PRF)membrane covering the surface of Bio-oss bone graft material on the soft tissue augmentation of dental implants in the aesthetic area of anterior teeth and its aesthetic effect.Methods A total of 80 patients receiving implantation(single tooth)in the aesthetic area of anterior teeth were selected and divided into the control group(n=40)and the research group(n=40)by random number table method.In the control group,the surface of Bio-oss bone graft material was covered with Bio-gide biofilm,and in the research group the surface of Bio-oss bone material was covered with PRF film.Wound healing time in the implantation area,excellent and good rate of implantation,soft tissue increment(increase in width of attached gingiva,increment in thickness of attached gingiva)after implantation,occlusal force,chewing efficiency,inflammatory factors of gingival crevicular fluid[high sensitivity C-reactive protein(hs-CRP),matrix metalloproteinase-2(MMP-2),interleukin-6(IL-6)]levels,anterior teeth esthetics[pink ethetic scot(PES),white esthetic score(WES)]were compared between two groups.Results The wound healing time in the implantation area in the research group was shorter than that of the control group,and the excellent and good rate of implantation was higher than that of the control group(P<0.05).At 3 months and 6 months after implantation,the increment of gingival width and gingival thickness of the research group was greater than that of the control group,and the difference was statistically significant(P<0.05).The increment of gingival width and gingival thickness of the research group at 6 months after implantation was greater than that of the control group at 3 months after implantation,and the difference was statistically significant(P<0.05).At 6 months after implantation,the occlusal force and masticatory efficiency of the two groups were higher than those immediately after implantation,which were higher in the research group than in the control group,and t

关 键 词：牙种植 富血小板纤维蛋白 美学 

分 类 号：R782.12[医药卫生—口腔医学]