表皮生长因子样结构域-7在宫颈癌组织中的表达及其与临床病理特征和预后的关系  

Expression of epidermal growth factor-like domain-7 in cervical cancer tissue and its relationship with clinical pathological characteristics and prognosis

作　　者：夏程程 唱润红 曹玉萍 XIA Chengcheng;CHANG Runhong;CAO Yuping(Department of Gynecology,Dalian Fifth People's Hospital,Dalian,Liaoning,116021,China)

机构地区：[1]大连市第五人民医院妇科,辽宁大连116021

出　　处：《当代医学》2023年第20期5-8,共4页Contemporary Medicine

摘　　要：目的探究表皮生长因子样结构域-7(EGFL7)在宫颈癌组织中的表达及其与临床病理特征和预后的关系。方法选取2015年2月至2016年3月于大连市第五人民医院妇科住院治疗的宫颈癌患者(n=40)及非宫颈癌患者(n=20)作为研究对象。采集宫颈癌患者宫颈癌组织及非宫颈癌患者正常宫颈组织,采用免疫组化法检测EGFL7在宫颈癌组织及正常宫颈组织中的表达水平,并分析EGFL7表达水平与宫颈癌患者临床病理特征和预后的关系。结果宫颈癌组织中EGFL7阳性表达率为70.00%,高于正常宫颈组织的10.00%,差异有统计学意义(P<0.05)。EGFL7表达水平与宫颈癌患者脉管浸润相关(P<0.05);与患者年龄、分化程度、组织类型、浸润深度、国际妇产科联盟(FIGO)分期及淋巴结转移无关。EGFL7阳性表达患者中位生存期为15.97个月,短于EGFL7阴性表达患者的26.70个月,差异有统计学意义(P<0.05)。经COX比例风险回归模型分析,脉管浸润及EGFL7高表达均为影响宫颈癌患者预后的独立风险因素(P<0.05)。结论EGFL7高表达于宫颈癌组织,其表达水平与宫颈癌患者FIGO分期及脉管浸润相关,且脉管浸润及EGFL7表达水平均为影响宫颈癌患者预后的独立风险因素,EGFL7有望成为肿瘤治疗的新靶点,可为探究宫颈癌预后分子标志物提供新的参考。Objective To investigate the expression of epidermal growth factor-like domain-7(EGFL7)in cervical cancer tissue and its relation-ship with clinical pathological characteristics and prognosis.Methods Patients with cervical cancer(n=40)and patients without cervical cancer(n=20)who were admitted to the Gynecology department of Dalian Fifth People's Hospital from February 2015 to March 2016 were selected as the study subjects.Cervical cancer tissue from patients with cervical cancer and normal cervical tissues from patients without cervical cancer were col-lected,the expression level of EGFL7 in cervical cancer tissues and normal cervical tissues was detected by immunohistochemical method,and the relationship between EGFL7 expression level and clinicopathological characteristics and prognosis of patients with cervical cancer was analyzed.Results The positive expression rate of EGFL7 in cervical cancer tissue was 70.00%,which was higher than 10.00%in normal cervical tissue,and the difference was statistically significant(P<0.05).The expression level of EGFL7 was correlated with vascular infiltration in patients with cervi-cal cancer(P<0.05);it was not related to patient age,degree of differentiation,tissue type,depth of infiltration,International Federation of Gyne-cology and Obstetrics(FIGO)stage and lymph node metastasis.The median survival time of patients with EGFL7-positive expression was 15.97 months,which was shorter than 26.70 months of patients with EGFL7-negative expression,and the difference was statistically significant(P<0.05).COX proportional risk regression model showed that vascular infiltration and high expression of EGFL7 were independent risk factors affect-ing the prognosis of cervical cancer patients(P<0.05).Conclusion EGFL7 is highly expressed in cervical cancer tissue,and its expression level is related to FIGO stage and vascular infiltration in cervical cancer patients,and both vascular infiltration and EGFL7 high expression are independent risk factors affecting the prognosis of cervical canc

关 键 词：表皮生长因子样结构域-7 宫颈癌 临床病理特征 预后 

分 类 号：R737.33[医药卫生—肿瘤]