基于“肺-脑-肠”轴理论探析微生物群与特发性肺纤维化  

Study on microbiota and idiopathic pulmonary fibrosis based on‘lung-brain-intestine’axis theory

作　　者：邹吉宇 庞立健[2] 吕晓东[1] 张春辉 臧凝子[2] 王天娇 ZOU Jiyu;PANG Lijian;LYU Xiaodong;ZHANG Chunhui;ZANG Ningzi;WANG Tianjiao(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)

机构地区：[1]辽宁中医药大学,沈阳110847 [2]辽宁中医药大学附属医院,沈阳110032

出　　处：《中华中医药杂志》2023年第10期5014-5018,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金面上项目(No.82274440);国家自然科学基金青年科学基金项目(No.82004294);辽宁省“兴辽英才计划”高水平创新团队项目(No.XLYC1808011)。

摘　　要：特发性肺纤维化(IPF)为“肺络病”范畴,肺络、脑络、肠络之间以络脉相系,“肺”“脑”“肠”三者在生理及病理上紧密相连,形成“肺-脑-肠”轴环形体系。微生物群在“肺-脑-肠”轴之间进行多向交互串扰,微生物群失调影响IPF的发生、发展及治疗多个环节。文章基于“肺-脑-肠”轴理论阐述微生物群失调影响IPF发生发展的多个环节,为IPF的治疗提供新思路。Idiopathic pulmonary fibrosis(IPF)belongs to the category of‘pulmonary collaterals disease’,The pulmonary collaterals,brain collaterals and intestinal collaterals are connected by collaterals.‘Lung’‘brain’and‘intestine’are closely connected in physiology and pathology,forming a ring system of lung-brain-intestine'axis.The microbiota interacts and crosstalks in multiple directions between the‘lung-brain-intestine’axis.The imbalance of microbiota affects the occurrence,development and treatment of IPF.Based on the‘lung-brain-intestine’axis theory,this paper expounds the correlation between microbiota and IPF,and provides a new idea for the treatment of IPF.

关 键 词：微生物群 特发性肺纤维化 “肺-脑”轴 “肠-脑”轴 “肺-肠”轴 肺络病 

分 类 号：R259[医药卫生—中西医结合]