肝主疏泄的现代生物学机制  

Biological mechanisms of liver controlling conveyance and dispersion

作　　者：王蓉燕齐 郝闻致 刘玥芸 薛哲 雷超芳 陈剑北 陈家旭 WANG Rongyanqi;HAO Wenzhi;LIU Yueyun;XUE Zhe;LEI Chaofang;CHEN Jianbei;CHEN Jiaxu(School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;School of Traditional Chinese Medicine,Jinan University,Guangzhou 510632,China)

机构地区：[1]北京中医药大学中医学院,北京100029 [2]暨南大学中医学院,广州510632

出　　处：《中华中医药杂志》2023年第10期5018-5022,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金面上项目(No.82174278)。

摘　　要：肝主疏泄是肝脏燮理阴阳、总统气血、斡旋枢机生理功能的核心,是维持机体内稳态整体自主调控的关键。现代研究表明,肝主疏泄的本质是机体自主神经信息产生、传导以及调控的过程,依赖于神经-内分泌-免疫网络系统,涉及中枢、外周的效应器官,具有多层次、多靶点的特征。中枢神经-边缘系统、中枢-内分泌-平滑肌以及肠道微生物-免疫-脑轴系统实现的信息传导、外周调节与动态反馈是肝疏泄气机以助心调神、助肺理气、助脾运化、助肾藏精的生理学基础。方证相应研究也揭示神经-内分泌-免疫网络调节是疏肝理气复方的重要药效机制。As we all know,liver controls conveyance and dispersion.It is the core of managing yin and yang,governing qi and blood,and adjusting pivot and movement.Modern researches proved that the essence of liver controlling conveyance and dispersion is the process of information production,transmission and regulation in autonomic nervous basing on neuroendocrineimmune network.This process needs cooperation of central nervous system,organs,peripheral tissues and blood.Therefore,it is complete and comprehensive with multi-level and multi-target.In this review,we concluded the physiological basis of liver controlling conveyance and dispersion is the information transmission,peripheral regulation and dynamic feedback through central nervous-limbic system,central endocrine-smooth muscle and intestinal microbial-immune-brain axis system.What's more,they are the basis for the liver to assist other organs with regulating the spirit,upbearing and effusion,purification and down-sending diffusion,transportation and transformation,absorption of Qi and essence.

关 键 词：肝主疏泄 神经-内分泌-免疫网络 脏腑 疏肝理气 生物学 

分 类 号：R223[医药卫生—中医基础理论]