热休克蛋白70在抑郁症中的作用及机制  

The role of heat shock protein 70 in depression and its mechanisms

作　　者：李晨[1] 肖玲[1] 谢银平 司璐佳 孙丽敏 元国豪 葛海龙 王高华[1] Li Chen;Xiao Ling;Xie Yinping;Si Lujia;Sun Limin;Yuan Guohao;Ge Hailong;Wang Gaohua(Department of Psychiatry,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院精神科,武汉430060

出　　处：《中华行为医学与脑科学杂志》2023年第9期853-858,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金(81871072, 82071523);武汉大学腾飞计划(TFLC2018001);湖北省重点研发项目(2020BCA064)。

摘　　要：作为常见的精神疾病,抑郁症病因复杂,发病机制尚未完全明确。抑郁症诊断主要依赖患者的病史、临床症状及相关检查,缺乏精确的诊断和治疗方式。寻找相关的生物学标志物,将会给抑郁症的诊断和靶向治疗提供重要的线索。在抑郁症的病因机制中,神经递质失衡、下丘脑-垂体-肾上腺轴亢进、神经元可塑性、神经炎性反应等学说已被广泛认可,氧化应激也参与了抑郁症的发生。大量研究发现,抑郁症患者热休克蛋白70(heat shock protein 70,HSP70)水平会在早期升高,以应对体内的应激状态。低水平的HSP70又和更严重的抑郁样行为相关联,可能是HSP70的降低导致的促氧化和促炎性反应所致。HSP70可能通过氧化应激、糖皮质激素受体、神经炎性反应及神经可塑性多种途径参与抑郁症的发生。此外,增加HSP70表达后,动物的抑郁样行为得到明显改善。因此,HSP70具有作为抑郁症的早期预警标志物以及药物靶点的潜在价值。As a common psychiatric disorder,the etiology and pathogenesis of depression are complex and not yet fully elucidated.The diagnosis of depression mainly depends on the patients’medical history,clinical symptoms and related examinations.Identification of biomarkers will provide important clues for the specific diagnosis and targeted treatment of depression.In addition to the widely recognized neurotransmitter dysregulation,hypothalamus-pituitary-adrenal axis hyperactivity,neuroplasticity,and neuro-inflammation theory,oxidative stress is also involved in the pathogenesis of depression in multiple ways.Many studies showed that the heat shock protein 70(HSP70)levels will increase in early stage to cope with the stress in patients with depression.However,lower HSP70 levels are often correlated with more severe depressive symptoms.HSP70 may be involved in depression through multiple pathways of oxidative stress,glucocorticoid receptors,neuroinflammation and neuroplasticity.Furthermore,increasing HSP70 expression results in significant improvement in depression-like behavior in animals.Thus,HSP70 possesses potential value as an early warning marker for depression as well as a therapeutic target.

关 键 词：抑郁症 热休克蛋白70 氧化性应激 糖皮质激素受体 神经元可塑性 

分 类 号：R749.4[医药卫生—神经病学与精神病学]