阴道微环境和HPV感染与CIN的关系研究  

Study on the relationship between vaginal microenvironment,HPV infection and CIN

作　　者：罗昌琴 何燕 孙艳霞 马秀萍[1] Luo Changqin;He Yan;Sun Yanxia;Ma Xiuping(Gynecology,Changji Branch of the First Affliated Hospital of Xinjiang Medical University(The Second People's Hospital of Changji and Changji Hospital of Traditional Chinese Medicine),Changji 831100,China;Gynecology,The First Affliated Hospital of Xinjiang Medical University,Changji 831100,China)

机构地区：[1]新疆医科大学第一附属医院昌吉分院(昌吉市第二人民医院、昌吉市中医医院)妇科,新疆昌吉831100 [2]新疆医科大学第一附属医院妇科,新疆昌吉831100

出　　处：《实用妇科内分泌电子杂志》2023年第16期1-3,共3页Electronic Journal of Practical Gynecological Endocrinology

基　　金：2021年新疆维吾尔自治区科技计划项目(编号2021D01A177)。

摘　　要：目的 分析阴道微环境和人乳头瘤病毒(HPV)感染与宫颈上皮内瘤变(CIN)的关系。方法 选取180例CIN患者,其中CINⅠ级110例纳入LSIL组,CINⅡ~Ⅲ级70例纳入HSIL组;另选取同期正常健康180例作为对照组。分析CIN发生的影响因素。结果 Logistic回归分析显示:HPV感染、细菌性阴道病(BV)、霉菌性阴道炎(VVC)、白介素-2(IL-2)降低、白介素-4(IL-4)增高、干扰素-γ(IFN-γ)降低是LSIL发生的危险因素(P<0.05);首次性交年龄<20岁、HPV感染、BV、滴虫性阴道炎(TV)、VVC、IL-2降低、IL-4增高、IFN-γ降低是HSIL发生的危险因素(P<0.05)。结论 宫颈CIN与阴道微环境、HPV感染均有密切关联,均会提高CIN的发生风险,临床应采取积极干预措施。Objective To analyze the relationship between vaginal microenvironment and human papillomavirus(HPV)infection and cervical intraepithelial neoplasia(CIN).Methods 180 patients with CIN were selected,of which 110 patients with CIN grade I were included in the LSIL group and 70 patients with CIN grade Ⅱto Ⅲ were included in the HSIL group.Another 180 normal females were selected as control group.The influencing factors of CIN were analyzed.Results Logistic regression analysis showed that HPV infection,bacterial vaginosis(BV),mycotic vaginitis(VVC),decreased interleukin-2(IL-2),increased interleukin-4(IL-4)and decreased interferon-γ(IFN-γ)were the risk factors for LSIL(P<0.05).Age of first sexual intercourse<20 years old,HPV infection,BV,trichomoniasis vaginitis(TV),VVC,decreased IL-2,increased IL-4 and decreased IFN-γ were risk factors for HSIL(P<005).Conclusion Cervical CIN is closely related to vaginal microenvironment and HPV infection,both of which increase the risk of cIN.Active intervention measures should be taken clinically.

关 键 词：宫颈上皮内瘤变 阴道微环境 人乳头瘤病毒感染 

分 类 号：R737.33[医药卫生—肿瘤]