外周T细胞淋巴瘤患者化疗后并发医院肺部感染的相关因素  

Related Factors of Nosocomial Lung Infection in Patients with Peripheral T-Cell Lymphoma After Chemotherapy

作　　者：宁静[1] 杨建伟[1] 姚志华[2] 陈辉[3] NING Jing;YANG Jianwei;YAO Zhihua;CHEN Hui(PET-CT,Henan Tumor Hospital,Zhengzhou 450000,China;Lymphatic Breast Comprehensive Internal Medicine,Henan Tumor Hospital,Zhengzhou 450000,China;Venous Catheter Center,Henan Tumor Hospital,Zhengzhou 450000,China)

机构地区：[1]河南省肿瘤医院PET-CT,河南郑州450000 [2]河南省肿瘤医院淋巴乳腺综合内科,河南郑州450000 [3]河南省肿瘤医院静脉置管中心,河南郑州450000

出　　处：《河南医学研究》2023年第19期3471-3474,共4页Henan Medical Research

基　　金：河南省医学科技攻关计划项目(SB201902034)。

摘　　要：目的探讨外周T细胞淋巴瘤(PTCL)患者化疗后发生医院肺部感染的相关因素。方法回顾性分析河南省肿瘤医院2019年1月至2022年1月收治的167例PTCL患者的临床资料,根据化疗后是否并发医院肺部感染将其分为并发组(52例)和未并发组(115例)。采用单因素和多因素logistic回归分析PTCL化疗后并发医院肺部感染的危险因素,并绘制森林图进行logistic结果的可视化显示。结果单因素分析结果显示并发感染组和未并发感染组性别、体重指数、饮酒史、糖尿病史、高血压史、高脂血症、病理类型比较差异无统计学意义(P>0.05);并发组年龄≥60岁、吸烟史、肿瘤病程≥30 d、应用糖皮质激素、临床分期为Ⅲ~Ⅳ期、使用2种及2种以上化疗药物、血白蛋白<30 g·L^(-1)患者占比高于未并发组(P<0.05),首次治疗患者占比低于未并发组(P<0.05);多因素logistic回归分析显示,年龄≥60岁、吸烟史、临床分期Ⅲ~Ⅳ期、2种及2种以上化疗药物、血白蛋白<30 g·L^(-1)是PTCL患者化疗后并发医院肺部感染的危险因素(P<0.05),首次治疗为其保护因素(P<0.05)。结论年龄≥60岁、吸烟、临床分期Ⅲ~Ⅳ期、多次治疗、使用2种及2种以上化疗药物、血白蛋白<30 g·L^(-1)与PTCL患者化疗后易并发医院肺部感染密切相关。Objective To explore the related factors of nosocomial lung infection in patients with peripheral T-cell lymphoma(PTCL)after chemotherapy.Methods A retrospective analysis was conducted on the clinical data of 167 PTCL patients admitted to Henan Cancer Hospital from January 2019 to January 2022.They were divided into a concurrent group(52 cases)and a non concurrent group(115 cases)based on whether they were complicated with hospital pulmonary infection after chemotherapy.Single factor and multivariate logistic regression analysis were used to analyze the risk factors of nosocomial pulmonary infection after PTCL chemotherapy,and a forest map was drawn to visualize the logistic results.Results Univariate analysis showed that there was no significant difference in sex,body mass index,drinking history,diabetes history,hypertension history,hyperlipidemia and pathological type between the infection group and the non infection group(P>0.05).The concurrent group had a higher proportion of patients aged≥60 years,a history of smoking,a tumor course of≥30 days,the use of glucocorticoids,clinical staging of stageⅢ-Ⅳ,the use of two or more chemotherapy drugs and blood albumin<30 g·L^(-1) compared to the non concurrent group(P<0.05).The proportion of patients treated for the first time was lower than that of the non concurrent group(P<0.05).Multivariate logistic regression analysis showed that age≥60 years old,smoking history,clinical stagesⅢ-Ⅳ,two or more chemotherapy drugs and blood albumin<30 g·L^(-1) were risk factors for hospital acquired pulmonary infection in PTCL patients after chemotherapy(P<0.05),with first treatment being a protective factor(P<0.05).Conclusion Age≥60 years old,smoking,clinical stagesⅢ-Ⅳ,multiple treatments,use of two or more chemotherapy drugs and blood albumin<30 g·L^(-1) are closely related to the susceptibility of PTCL patients to hospital pulmonary infection after chemotherapy.

关 键 词：外周T细胞淋巴瘤 肺部感染 化疗 影响因素 

分 类 号：R733.4[医药卫生—肿瘤]