EPIYA基序与幽门螺杆菌感染相关胃病关系的研究进展  

Research progress in the relationship between EPIYA motif and Helicobacter pylori infection-associated gastropathy

作　　者：冯富娟 邵慧娟 江晶晶 于晓辉 郑晓凤[3] 张久聪 Feng Fujuan;Shao Huijuan;Jiang Jingjing;Yu Xiaohui;Zheng Xiaofeng;Zhang Jiucong(The First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou 730000,China;不详)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州730000 [2]中国人民解放军联勤保障部队第九四〇医院消化内科,兰州730050 [3]兰州大学第二医院消化内科,兰州730030

出　　处：《新医学》2023年第10期700-703,共4页Journal of New Medicine

基　　金：甘肃省自然科学基金面上项目(21JR7RA002);甘肃省自然科学基金青年项目(22JR5RA1012)。

摘　　要：幽门螺杆菌(Hp)是一种人类主要致病菌,人体在感染Hp后会引发慢性胃炎、消化性溃疡、胃癌等一系列胃肠道疾病。近年来,随着这些疾病的发病率升高,它们的病因及发病机制日益在世界范围内受到许多学者的关注。而Hp的毒力基因之一即细胞毒素相关基因A(CagA)的致病机制也因此受到重视,谷氨酸-脯氨酸-异亮氨酸-酪氨酸-丙氨酸组成的重复序列(EPIYA基序)与Hp感染相关胃病也成为目前研究的热点。该文就EPIYA基序与Hp感染相关胃病的关系作一简要综述。Helicobacter pylori(Hp)is a major human pathogen.Hp infection will cause a series of gastrointestinal diseases,such as chronic gastritis,peptic ulcer and gastric cancer,etc.In recent years,with the increasing incidence of these diseases,their etiology and pathogenesis have attracted more and more attention from many scholars around the world.The pathogenic mechanism of cytotoxin-associated gene A(CagA),one of the virulence genes of Hp,has captivated widespread attention.EPIYA motif and Hp infection-associated gastropathy have become a hot topic.In this article,the relationship between EPIYA motif and gastropathy related to Hp infection was briefly reviewed.

关 键 词：幽门螺杆菌 细胞毒素相关基因A 慢性胃炎 消化性溃疡 胃癌 

分 类 号：R573[医药卫生—消化系统]