血浆FIB与前列腺癌关系的研究进展  

Research progress in the relationship between plasma FIB and prostate cancer

作　　者：张鹏 韩从辉[1,2] 刘大闯 Zhang Peng;Han Conghui;Liu Dachuang(Graduate School of Bengbu Medical College,Bengbu 233030,China;不详)

机构地区：[1]蚌埠医学院研究生院,蚌埠233030 [2]徐州市中心医院泌尿外科,徐州221009

出　　处：《新医学》2023年第10期708-711,共4页Journal of New Medicine

基　　金：徐州市引进临床医学专家团队项目(2018TD004);江苏省徐州医科大学附属医院发展基金(XYFM2020001)。

摘　　要：前列腺癌好发于老年男性,发病率逐年上升。目前临床上仍以前列腺特异性抗原(PSA)作为诊断前列腺癌的标志物,但其准确度及灵敏度尚不够,探究更多的临床检验指标辅助诊断前列腺癌是目前研究的热点。恶性肿瘤患者大多处于高凝状态,有研究显示血浆纤维蛋白原(FIB)在前列腺癌中存在差异性表达,并有报道其可能作为前列腺癌的一种潜在促癌因素。该文就血浆FIB的发现、生物结构、生理功能、病理状态(炎症、肿瘤)下的变化及作用,尤其是血浆FIB与前列腺癌关系的相关研究进展进行系统综述,以期为临床相关研究提供参考。The incidence of prostate cancer(PCa)has been increased year by year,mainly occurring in elderly men.Currently,prostate-specific antigen(PSA)is still used as a marker for diagnosing PCa in clinical practice.However,the accuracy and sensitivity of PSA remain relatively low.Identifying more clinical detection parameters for assisting diagnosis becomes a research hotspot.Most of patients with malignant tumors are in a hypercoagulable state.Studies have found that plasma fibrinogen(FIB)is differentially expressed in PCa.In addition,FIB has been considered as a potential tumor-promoting factor in PCa.In this article,the discovery,biological structure,physiological function,pathological changes(inflammation and tumor)and functions of plasma FIB,especially the relationship between plasma FIB and PCa,were systematically reviewed,aiming to provide reference for relevant clinical research.

关 键 词：前列腺癌 血浆纤维蛋白原 促癌因素 

分 类 号：R737.25[医药卫生—肿瘤]