发酵技术在护肤品行业中的应用与展望——2023版·第5代发酵技术  

Application and prospect of fermentation technology in skin care industry:2023•the fifth generation fermentation technology

作　　者：马彦云[1] 赵心清[2] 刘玮 张婉萍 黄焱 吴志刚 MA Yan-yun;ZHAO Xin-qing;LIU Wei;ZHANG Wan-ping;HUANG Yan;WU Zhi-gang(Six-sector Industrial Research Institute,Fudan University,Shanghai 200433,China;State Key Laboratory of Microbial Metabolism,Shanghai Jiao Tong University,Shanghai 200240,China;Department of Dermatology,Air Force Medical Center,Beijing 100142,China;Shanghai Institute of Technology,Shanghai 201418,China;JI CHU YAN JIU,Shanghai 200433,China;OIB.CHINA,Shanghai 200431,China)

机构地区：[1]复旦大学六次产业研究院,上海200433 [2]上海交通大学微生物代谢国家重点实验室,上海200240 [3]空军特色医学中心皮肤科,北京100142 [4]上海应用技术大学,上海201418 [5]基础颜究,上海200433 [6]上海拜卓品牌管理有限公司,上海200431

出　　处：《日用化学品科学》2023年第10期71-82,共12页Detergent & Cosmetics

摘　　要：介绍了发酵的发展历程,综述了以护肤品行业为例,随着更多学科的引入和新兴技术的应用,发酵在不同时期下所呈现出的不同目的、阶段特点、所使用的技术以及代表性发酵产物,提出发酵可分为5个阶段:传统发酵阶段、工程化发展阶段、微生物学应用阶段、合成生物学阶段和智能发酵阶段,同时重点介绍了第5代发酵技术的特点、优势和产物功效,以极地酵母喜默因®为例,阐述了第5代发酵技术通过化学及生物信息学的手段,从“成分-靶点-机制-功效”的角度阐明喜默因多靶点抗老的功效机理。The evolution of fermentation technology was outlined,offering a comprehensive overview using the skincare industry as a case study/illustrative model.With the integration of various scientific disciplines and the application of emerging technologies,it discusses the diverse purposes,developmental phases,techniques,and prototypical fermentation products presented in various historical contests.Fermentation can be categorized into five stages:traditional fermentation,engineered development,microbiological applications,synthetic biology,and intelligent fermentation.Furthermore,the characteristics,advantages,and effectiveness of fifthgeneration fermentation technology were exphasized.Using HiMurchaSin®as an example,how fifth-generation fermentation technology employs a mechanistic exploration guided by‘constituents-efficacy-targets-mechanisms,’to achieve a multi-target anti-aging effect on the skin was explained.

关 键 词：发酵技术 第5代发酵护肤 智能发酵 多靶点抗老 

分 类 号：TQ658[化学工程—精细化工]