神经病理性疼痛动物模型的选择与建立  

Selection and establishment of animal models of neuropathic pain

作　　者：殷利军 陈辉[1,2,3,4] 熊利泽[1,2,3,4] YIN Lijun;CHEN Hui;XIONG Lize(Department of Anesthesiology and Perioperative medicine,Shanghai Fourth People's Hospital,School of Medicine,Tongji University,Shanghai 200434,China;Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation,Shanghai 200434,China;Translational Research Institute of Brain and Brain-Like Intelligence,Shanghai Fourth People's Hospital,School of Medicine,Tongji University,Shanghai 200434,China;Clinical Research Center for Anesthesiology and Perioperative Medicine,Tongji University,Shanghai 200434,China;Department of Anesthesiology,Ningbo Women and Children's Hospital,Ningbo 315012,China)

机构地区：[1]同济大学附属上海市第四人民医院麻醉与围术期医学科,上海200434 [2]上海市麻醉与脑功能调控重点实验室,上海200434 [3]同济大学附属上海市第四人民医院脑功能与人工智能转化研究所,上海200434 [4]同济大学麻醉与围术期医学临床研究中心,上海200434 [5]宁波市妇女儿童医院麻醉科,宁波315012

出　　处：《中国疼痛医学杂志》2023年第10期725-730,共6页Chinese Journal of Pain Medicine

基　　金：国家自然科学基金(81971042)。

摘　　要：神经病理性疼痛(neuropathic pain,NP)是临床上最常见的难治性慢性疼痛,已成为最具挑战性的公共健康问题之一。由于NP发病率高,致病机制复杂且尚未完全阐明,目前尚无有效的治疗和预防策略,严重影响病人的生活质量和身心健康。因此,有必要进一步深入研究NP的致病机制,为NP的治疗提供更多证据。选择与建立合适的疼痛动物模型是NP机制研究中需要解决的关键问题。目前动物模型多根据NP病因进行分类,不利于研究者对动物模型的筛选比较与建模。本文基于神经受损的方式,如单次损伤、持续损伤、全身疾病或药物诱导损伤等,对常见NP模型的动物选择和分类进行总结,以期为NP研究中动物模型的选择与建立提供有益的参考。Neuropathic pain(NP)is the most common refractory chronic pain in clinical practice and has become one of the most challenges in public health.NP has a relatively high incidence,the mechanism underlying the pathogenesis of NP is complex and remains to be elucidated,and thus there is no effective strategy for the treatment and prevention of NP,which has a serious impact on the quality of life and physical and mental health of patients.Therefore,it is necessary to further investigate the pathogenic mechanism of NP to provide more evidence for the treatment of NP.The selection and establishment of appropriate pain animal model are a key issue in the investigation of pathogenic mechanism of NP.Currently,animal models are mostly classified according to the etiology of NP,which is not conducive to the screening,comparison and modeling of animal models.Based on the types of nerve injury,such as single injury,persistent injury,systemic diseases or drug-induced injury,we summarize the selection and classification of common NP animal models,in order to provide useful reference for the selection and establishment of animal models for future NP studies.

关 键 词：神经病理性疼痛 动物模型 痛觉超敏 疼痛评估 

分 类 号：R741[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]