基于“治中焦如衡”论治慢性萎缩性胃炎炎症微环境中新生血管的失调和复衡  

Imbalance and counterbalance of neovascularization in microenvironment of chronie Atrophic gastritis inflammation based on the theory of‘Treating Middle Jiao as Balance’

作　　者：冯皓月 曾进浩 刘进 郭静[1] 夏婷 姚欢 邓嘉帅 FENG Haoyue;ZENG Jinhao;LIU Jin(Hospi-tal of Chengdu Unirersity of Trditionad Chinese Medicine,Chengdu Sichuon 610075,China;Mianyang Orhopredie hoapital,Mianyang Sichuan 621000,China)

机构地区：[1]成都中医药大学附属医院,四川成都610072 [2]绵阳市骨科医院,四川成都610000

出　　处：《四川中医》2023年第6期35-39,共5页Journal of Sichuan of Traditional Chinese Medicine

基　　金：国家自然科学基金委员会面上项目(编号:82174346);四川省中医药管理局项目(编号:2021MS104);成都中医药大学附属医院科技发展基金(编号:20MZ06)。

摘　　要：新生血管的生成是肿瘤发生、发展以及转移的重要因素,其在胃炎向胃癌(gastric cancer,GC)发展的慢性萎缩性胃炎(chronic atrophic gastritis,CAG)癌前状态环节即已萌芽。周细胞紊乱是血管生成失去自我调控的关键,也是加重CAG非可控性炎症状态,驱动组织恶性转变的重要因素。介导CAG炎症微环境与宿主“和平共处”的先决条件,是防治GC的关键。本文以周细胞为切入点,联合中医“治中焦如衡”理论,对周细胞在CAG癌前病变血管新生中的发展进程进行阐述,以期为“治中焦如衡”理论指导下运用中医药恢复周细胞的自我调控进而抑制血管新生,恢复CAG炎症微环境稳态以防治GC提供理论依据,为扩展中医药治疗本病提供新的参考。Neovascularization is an important factor in tumorigenesis,progression,and metastasis,and it germinates in the precancerous state of Chronic Atrophic Gastritis(CAG)in the progression from gastritis to Gastric Cancer(CC).Pericyte disrup-tion is the key to the loss of self-regulation of angiogenesis and is an important factor that exacerbates the uncontrollable inflamma-tory state of CAG and drive the malignant transformation of tissues.Mediating the prerequisites for the'peaceful coexistence'of the CAG inflammatory microenvironment and the host is the key to the prevention and treatment of CC.In this paper,we take pericytes as the entry point and combine the theory of‘Treating Middle Jiao as Balance'in TCM to elaborate the development process of pericytes in the vascularization of CAG precancerous lesions,with the aim of restoring the self-regulation of pericytes by TCM under the guidance of the theory of Treating Middle Jiao as Balance'and restoring the vascularization of CAG precan-cerous lesions.

关 键 词：慢性萎缩性胃炎 胃癌 新生血管 周细胞 治中焦如衡 

分 类 号：R573.32[医药卫生—消化系统]