纳米药物在肿瘤过继性细胞免疫治疗中的研究进展  

Research progress of nanomedicine in adoptive cell therapy for cancer

作　　者：杨艳[1,2] 钱汉清 马亚军 YANG Yan;QIAN Hanqing;MA Yajun(Jiangning Clinical Medicine School,Nanjing University of Traditional Chinese Medicine,Nanjing 211000;Department of Oncology,the Affiliated Jiangning Hospital of Nanjing Medical University,Nanjing 211000;Jiangning Clinical Medicine School,Jiangsu Vocational College of Medicine,Nanjing 211000,China)

机构地区：[1]南京中医药大学江宁临床医学院,江苏南京211000 [2]南京医科大学附属江宁医院肿瘤科,江苏南京211000 [3]江苏医药职业学院江宁临床医学院,江苏南京211000

出　　处：《南京医科大学学报（自然科学版）》2023年第10期1441-1449,共9页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(81972890,82272690);南京医科大学科技发展基金(NMUB2020160);南京中医药大学自然科学基金(XZR2020086);江苏医药职业学院临床教学基地科研发展专项课题(20219103);南京市医学科技发展项目(YKK20193);江宁区科技惠民计划项目(2022131S)。

摘　　要：肿瘤过继性细胞免疫治疗是一种新兴的肿瘤免疫治疗模式。通过回输经体外扩增活化的工程化免疫细胞,在患者体内激发有效的抗肿瘤免疫应答。然而,由于复杂的肿瘤免疫抑制微环境,免疫细胞易发生耗竭,难以穿透肿瘤深处,导致其在实体肿瘤中的疗效有限。近年来,纳米材料在肿瘤免疫治疗领域受到了广泛关注。纳米材料可以促进免疫细胞扩增、回输后体内存活和在肿瘤中的穿透与浸润,有助于免疫细胞克服实体肿瘤组织中的物理屏障和免疫抑制微环境,提高治疗效果。本文就目前纳米药物在肿瘤过继性细胞免疫治疗中应用的研究进展进行综述。Tumor adoptive cellular immunotherapy is a new model of tumor immunotherapy.It can induce effective anti⁃tumor immune response in patients by infusion the engineered immune cells which are amplified and activated in vitro.However,due to the complex tumor immunosuppressive microenvironment,immune cells are prone to exhaust and difficult to penetrate deep into the tumor,resulting in limited effect in solid tumors.In recent years,nanomaterials have received extensive attention in the field of tumor immunotherapy.Nanomaterials can promote the expansion of immune cells,their survival after in vivo infusion,and their infiltration in tumors,help immune cells to overcome the physical barriers and immunosuppressive microenvironment in solid tumor tissues,and improve the therapeutic effect.In this article,we reviewed the current research progress of the application of nanomedicine in tumor adoptive cellular immunotherapy.

关 键 词：过继性细胞免疫治疗 纳米材料 肿瘤 免疫抑制微环境 

分 类 号：R730.51[医药卫生—肿瘤]