鞘胺醇-1-磷酸受体1选择性调节剂的研究进展  

Research Progress of Sphingosine-1-Phosphate Receptor 1 Selective Modulators

作　　者：王茜茜 江程[1] WANG Qianqian;JIANG Cheng(School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学药学院,江苏南京211198

出　　处：《药学进展》2023年第8期626-636,共11页Progress in Pharmaceutical Sciences

摘　　要：鞘氨醇-1-磷酸(sphingosine-1-phosphate,S1P)是调节细胞内外多种生物学功能的重要信号分子。S1P通过结合5种G蛋白偶联受体(G protein-coupled receptors,GPCRs)亚型介导多重下游信号通路产生相关的细胞生理功能。近年来,对选择性鞘氨醇-1-磷酸受体1(sphingosine-1-phosphate receptor 1,S1PR1)调节剂的研究已成为发现免疫性疾病治疗药物的热点。综述总结了近年来S1PR1调节剂的研究进展,对构效关系进行了讨论,并在此基础上探讨了此类调节剂的发展方向。Sphingosine-1-phosphate(S1P)is an important signaling molecule that regulates multiple biological functions inside and outside cells.It mediates multiple downstream signaling pathways through binding to five G protein-coupled receptor subtypes to produce related physiological functions of cells.In recent years,the study of selective sphingosine-1-phosphate receptor 1(S1PR1)modulators has become a hot spot in the discovery of therapeutic drugs against immune diseases.This review summarizes the research progress of S1PR1 modulators in recent years,and discusses the structure-activity relationship and the development direction of such modulators.

关 键 词：鞘氨醇-1-磷酸 鞘氨醇-1-磷酸受体1调节剂 免疫性疾病 构效关系 

分 类 号：R914.2[医药卫生—药物化学]